# Research Progress on the Relationship between Intratumor Microbiota and Lung Cancer

**Authors:** Yangtong ZHU, Jiawei CHEN, Yanqian ZHU, Linyu WU

PMC · DOI: 10.3779/j.issn.1009-3419.2025.101.05 · Chinese Journal of Lung Cancer · 2025-04-20

## TL;DR

This paper reviews how the microbiota inside lung tumors affects cancer development and its potential use in diagnosis and treatment.

## Contribution

It systematically summarizes recent advances in intratumor microbiota research specific to lung cancer.

## Key findings

- Intratumor microbiota influences lung cancer development through multiple mechanisms.
- Tumor microbiota shows potential as a biomarker for diagnosis and prognosis.
- Modulating intratumor microbiota may offer new therapeutic strategies for lung cancer.

## Abstract

肺癌的发病率和死亡率在全球癌症中居于首位。近年来，随着微生物检测技术的发展，肿瘤内微生物群逐渐成为肺癌研究领域的热点和前沿。研究发现存在于肿瘤内的微生物群可以通过多种方式影响肺癌的发生发展。此外，肿瘤内微生物群可以作为肺癌诊断和预后评估的潜在生物标志物，通过调节肺癌瘤内微生物群有望成为新型的肺癌治疗方式。本文将系统综述肿瘤内微生物群与肺癌相关的最新研究进展，总结肺癌瘤内微生物群的来源和特征，探讨其影响肺癌发生发展的机制，并展望其在肺癌诊断、治疗和预后中的应用前景。

## Linked entities

- **Diseases:** lung cancer (MONDO:0005138)

## Full-text entities

- **Diseases:** cancer (MESH:D009369), Lung Cancer (MESH:D008175)

## Full text

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## References

37 references — full list in the complete paper: https://tomesphere.com/paper/PMC12096095/full.md

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Source: https://tomesphere.com/paper/PMC12096095