# Successful Transplantation of Multiple Organs from Donor after Helium Asphyxiation: First Case Report in Japan

## TL;DR

This paper reports the first case in Japan of successful organ donation from a brain-dead donor who died after helium asphyxiation.

## Contribution

The novelty is demonstrating that helium-induced brain death can lead to viable organ donation.

## Key findings

- Brain death from helium asphyxiation did not prevent successful organ transplantation.
- Multiple organs including heart, lungs, liver, and kidneys were transplanted and functioned well.
- No complications were observed in organ grafts at the 3-month follow-up.

## Abstract

Helium inhalation has increased, but most cases are either minor injuries or deaths; there have not yet been any reported cases of brain death leading to organ donation. We report a patient who attempted helium inhalation and was declared brain dead and became an organ donor without complications. To the best of our knowledge, this is the first reported case of deceased organ donation following helium asphyxiation in Japan. The patient in cardiac arrest was found with a helium-filled vinyl bag sealed around the neck. During emergency medical transport to the hospital, a spontaneous return of circulation was obtained after 31 minutes of cardiopulmonary resuscitation. Upon hospital arrival, the physical examination revealed dilated pupils with no response to light. Electrocardiography showed widespread ST-segment depression and ST-segment elevation in augmented Vector Right, as well as elevated cardiac enzymes and decreased myocardial contractility. Head computed tomography revealed diffuse cerebral edema and loss of the gray-white matter boundary without signs of air embolism in the cerebral and coronary arteries. Despite comprehensive post-cardiac arrest care with recovery of organ function, brain death was confirmed on day 4 after hospitalization. The family consented to organ donation on the 11th day of hospitalization. The heart, lungs, liver, and two kidneys were successfully transplanted and all organs functioned. All organ grafts were functioning well at the 3-month follow-up. Our case demonstrates that brain death caused by helium inhalation is not a contraindication to organ donation.