# Synchronous neuroendocrine tumor and signet ring cell carcinoma in the stomach: a case report and review of literature

## TL;DR

A 66-year-old man had two rare stomach tumors at the same time: a signet ring cell carcinoma and a neuroendocrine tumor.

## Contribution

This case report documents a rare synchronous occurrence of two distinct gastric tumors in a single patient.

## Key findings

- A submucosal tumor-like mass was diagnosed as signet ring cell carcinoma via biopsy.
- A separate 6-mm protrusion was identified as a neuroendocrine tumor through biopsy.
- The patient underwent total gastrectomy and was confirmed to have synchronous gastric neoplasms.

## Abstract

Synchronous neoplasms of the stomach are uncommon. Here we presented an unusual case with coexistence of neuroendocrine tumor and signet ring cell carcinoma in the stomach. Gastroscopic examination of a 66-year-old male patient showed a submucosal tumor-like mass with an ulcer on the surface located in the anterior wall of the lower segment of gastric body, confirmed by subsequent biopsy as a signet ring cell carcinoma. Moreover, we also found a slightly yellowish 6-mm protrusion simulating a polyp located in the lesser curvature of the upper segment of gastric body, and biopsy revealed it was a neuroendocrine tumor. The patient underwent a total gastrectomy with a standard D2 lymph node dissection. Pathohistological results led to the final diagnosis of synchronous neoplasms in the stomach, including a signet ring cell carcinoma and a neuroendocrine tumor.