# Effectiveness of herbal medicine for liver cancer treatment as revealed by a bibliometric and visualization analysis

## TL;DR

This study analyzes global research trends in herbal medicine for liver cancer, highlighting key contributors, topics, and future directions.

## Contribution

The paper provides a novel bibliometric and visualization analysis of herbal medicine research for liver cancer, identifying emerging trends and key contributors.

## Key findings

- Chinese researchers, especially from Shanghai University of Traditional Chinese Medicine, dominate the field.
- Keywords like 'NF kappa B' and apoptosis are central, while 'network pharmacology' and antioxidants are emerging topics.
- Research is primarily published in molecular biology and immunology journals, with cited works in environment, toxicology, and nutrition.

## Abstract

Liver cancer is highly prevalent worldwide. However, current medical treatments remain insufficient. Although herbal medicine has a long history and extensive expertise in treating liver cancer, the literature in this field has not been thoroughly explored. This study aims to assess and analyze the distribution patterns and key research areas of publications concerning herbal medicine for liver cancer.

Literature on herbal medicine and liver cancer published between January 1, 2008, and September 28, 2024, was collected for this research. Excel, CiteSpace 6.4.R1, VOSviewer 1.6.20, Scimago Graphica, and Bibliometrix 4.1 were used for data analysis.

The study examines 634 academic articles on herbal medicine for liver cancer, with the majority contributed by Chinese researchers, particularly from Shanghai University of Traditional Chinese Medicine. Wang Ning is the most productive author, possessing the highest h-index. The JOURNAL OF ETHNOPHARMACOLOGY has the most publications and the highest h-index. Journals publishing on herbal medicine and liver cancer are primarily in the fields of molecular biology and immunology, whereas the cited journals are mainly in the fields of environment, toxicology, and nutrition. Keyword clustering analysis indicates that “NF kappa B” and apoptosis have long been the main research topics in this field. Analysis of emergent words suggests that “network pharmacology”, antioxidants, “adjuvant therapy”, and “molecular docking” may become significant research topics in the near future.

This analysis provides a comprehensive overview of the current status, primary focuses, and emerging trends in research related to herbal medicine and liver cancer.