# Cutaneous Implications of Liver Cirrhosis: A Case of Acrodermatitis Enteropathica

**Authors:** Sameera Shuaibi, Najat AlSejari, Samer Farhud, Jeanne Nguyen, Caley McIntyre

PMC · DOI: 10.7759/cureus.82734 · Cureus · 2025-04-21

## TL;DR

This paper discusses a case where liver cirrhosis led to a rare skin condition caused by zinc deficiency.

## Contribution

The paper presents a novel case linking decompensated liver cirrhosis to acrodermatitis enteropathica.

## Key findings

- A case of AE was observed in a patient with decompensated liver cirrhosis.
- Severe skin lesions were attributed to zinc deficiency caused by liver disease.

## Abstract

Acrodermatitis enteropathica (AE) is characterized by a constellation of symptoms that result from a deficiency in serum zinc levels. The commonest cause of AE is hereditary autosomal recessive genetic mutations that impair zinc absorption in the small intestine, while acquired causes come second. Liver disease has been implicated in the development of acquired zinc deficiency. Herein, we present a case of AE with severe exfoliative skin lesions that occurred secondary to decompensated liver cirrhosis.

## Linked entities

- **Chemicals:** zinc (PubChem CID 23994)
- **Diseases:** Acrodermatitis enteropathica (MONDO:0008713)

## Full-text entities

- **Diseases:** zinc deficiency (MESH:C564286), Liver Cirrhosis (MESH:D008103), skin lesions (MESH:D012871), Acrodermatitis Enteropathica (MESH:C538178), Liver disease (MESH:D008107)
- **Chemicals:** zinc (MESH:D015032)

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12094836/full.md

## References

13 references — full list in the complete paper: https://tomesphere.com/paper/PMC12094836/full.md

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Source: https://tomesphere.com/paper/PMC12094836