# Adult-Onset Immunoglobulin A Vasculitis (IgAV) Presenting in a Middle-Aged Indian Male Patient

**Authors:** Abdalla Khalil, Naomi Oldham, Saju Beepaul, Elvin Chang

PMC · DOI: 10.7759/cureus.82735 · Cureus · 2025-04-21

## TL;DR

A middle-aged Indian man was diagnosed with adult-onset IgA vasculitis after showing symptoms like chest pain, abdominal pain, and rash.

## Contribution

This case highlights IgAV in an adult male, which is less commonly reported than in children.

## Key findings

- The patient showed elevated IgA levels and IgA deposition confirmed by skin biopsy.
- He responded well to oral steroids with reduced inflammation.
- The case demonstrates gastrointestinal and skin involvement typical of IgAV.

## Abstract

Immunoglobulin A vasculitis (IgAV) is a small vessel vasculitis that mainly affects the skin, gastrointestinal tract, and kidneys.

We present a case of a middle-aged male patient who presented to the emergency department with lower chest pain, colicky abdominal pain, and painful petechial rash. His inflammatory markers and IgA were raised with mild proteinuria.

Abdominal CT and endoscopy revealed gastrointestinal involvement, and immunofluorescence skin biopsy confirmed IgA deposition in the dermal vessels. He responded clinically to oral steroids, and his inflammatory markers trended down. After six days, he was discharged.

## Linked entities

- **Diseases:** Immunoglobulin A vasculitis (MONDO:0019167), proteinuria (MONDO:0003634)

## Full-text entities

- **Genes:** CD79A (CD79a molecule) [NCBI Gene 973] {aka IGA, IGAlpha, MB-1, MB1}
- **Diseases:** chest pain (MESH:D002637), inflammatory (MESH:D007249), proteinuria (MESH:D011507), IgAV (MESH:D014657), abdominal pain (MESH:D015746), petechial rash (MESH:D005076), small vessel vasculitis (MESH:C565222)
- **Chemicals:** steroids (MESH:D013256)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12094833/full.md

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12094833/full.md

## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC12094833/full.md

---
Source: https://tomesphere.com/paper/PMC12094833