# Prevalence of ophthalmic abnormalities and refractive changes in Taiwanese children with Down syndrome

## TL;DR

This study finds that most Taiwanese children with Down syndrome have significant refractive errors, especially astigmatism, highlighting the need for regular eye exams.

## Contribution

The study provides new data on ophthalmic disorders in Taiwanese children with Down syndrome, showing higher astigmatism rates than previous Asian studies.

## Key findings

- 75.7% of children had visually significant refractive errors, with astigmatism being the most common.
- Annual refractive change was −0.16 ± 0.65 diopters, influenced by age and baseline spherical equivalence.
- The cohort showed higher astigmatism prevalence compared to prior studies of Asian children with Down syndrome.

## Abstract

Ophthalmological manifestations in children with Down syndrome remain significantly underdiagnosed, particularly in Asian populations. This study aimed to investigate the prevalence and characteristics of ophthalmic disorders in Taiwanese children with Down syndrome, analyze their refractive changes over time, and compare findings with existing research across diverse ethnic populations.

Comprehensive ophthalmologic examinations were conducted on 148 Taiwanese children with Down syndrome, documenting age, sex, medical history, ocular alignment, visual acuity, and cycloplegic refraction. Annual refractive change assessments were performed using multivariate linear regression analysis for subjects with minimum one-year follow-up.

Visually significant refractive errors were identified in 75.7% of subjects, with astigmatism being most prevalent (70.3%), followed by hyperopia (31.8%) and myopia (19.6%). Our cohort showed higher astigmatism prevalence compared to previous studies of Asian children with Down syndrome. Longitudinal analysis revealed an annual refractive change of −0.16 ± 0.65 diopters, with age and baseline spherical equivalence emerging as significant contributing factors.

This study provides unprecedented data on ophthalmic disorders and refractive changes in Taiwanese children with Down syndrome. The high prevalence of refractive errors, particularly astigmatism, underscores the importance of early and regular screening in this population. These findings may inform the development of targeted screening protocols and optimal intervention timing.