# Familial Thoracic Aortic Aneurysm and Dissection: Simultaneous Presentation in Two Brothers

**Authors:** Kunal Karmilkar, Lis M Llanio, Kyle Maisel, Adesoji Adenigbagbe

PMC · DOI: 10.7759/cureus.82697 · 2025-04-21

## TL;DR

Two brothers from a family with a history of aortic disease both experienced severe aortic issues, highlighting the importance of early detection and management.

## Contribution

This case report emphasizes the need for early identification and management of familial thoracic aortic aneurysm and dissection.

## Key findings

- Two Jamaican brothers presented with acute aortic dissections following a sibling's death from FTAAD.
- Early identification and specific management strategies are crucial to prevent life-threatening aortic events.
- Literature review highlights gaps in diagnosing and managing inherited aortic conditions.

## Abstract

Familial thoracic aortic aneurysm and dissection (FTAAD) is an inherited condition with variable penetrance, often leading to life-threatening aortic events. We report the cases of two Jamaican brothers who developed acute aortic dissections following the death of a sibling from FTAAD. We reviewed recent literature regarding patient demographics, genetic variability, diagnostic modalities, and management strategies for similar cases. Despite the availability of guidelines, early identification of at-risk individuals and specific management strategies are essential to prevent life-threatening events.

## Linked entities

- **Diseases:** thoracic aortic aneurysm (MONDO:0005396), FTAAD (MONDO:0019625)

## Full-text entities

- **Diseases:** FTAAD (MESH:C562834), aortic dissections (MESH:D000784)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12094197/full.md

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Source: https://tomesphere.com/paper/PMC12094197