# Foundational basic animal experiments paved the way for the clinical development of uterus transplantation

## TL;DR

Animal experiments were crucial in developing uterus transplantation as a treatment for infertility, with Japan's research and global efforts advancing its clinical use.

## Contribution

This paper highlights Japan's non-human primate research and regulatory progress in advancing uterus transplantation toward clinical implementation.

## Key findings

- Animal studies were pivotal in translating uterus transplantation to clinical practice.
- Japan's research and regulatory efforts are leading to clinical implementation of UTx.
- Global expansion of UTx in the Asia-Oceania region is noted.

## Abstract

Uterus transplantation (UTx) has emerged as a revolutionary treatment for absolute uterine factor infertility, made possible by extensive preclinical research. Animal studies have played a pivotal role in advancing UTx to clinical practice. We highlight Japan's contribution, including non‐human primate research and regulatory progress, leading to its anticipated clinical implementation. The expansion of UTx in the Asia‐Oceania region underscores its global impact. Further refinements in surgical techniques, optimization of immunosuppressive regimens, and establishment of clear patient eligibility criteria will be crucial for ensuring the long‐term success and sustainability of UTx programs worldwide. This letter acknowledges the Swedish team's foundational efforts in establishing UTx as a viable reproductive technology.