# Front Cover

## TL;DR

Reducing HSP60 in microglia causes synaptic issues and depression-like behaviors in male mice due to increased synaptic pruning.

## Contribution

Shows a novel link between HSP60 depletion in microglia and depression-like behaviors via synaptic pruning.

## Key findings

- HSP60 depletion in microglia leads to synaptic dysfunction in male mice.
- Enhanced synaptic pruning contributes to depression-like behaviors.
- The study highlights a potential role of HSP60 in mental health.

## Abstract

The cover image is based on the article Depletion of HSP60 in Microglia Leads to Synaptic Dysfunction and Depression‐Like Behaviors Through Enhanced Synaptic Pruning in Male Mice by Wenhui Zhu et al., https://doi.org/10.1111/cns.70394.