Homogenization Reveals Large-Scale Dynamics in the Spread of Chronic Wasting Disease
Jen McClure, James Powell
TL;DR
This paper shows how chronic wasting disease spreads through wildlife by combining direct and indirect transmission, using mathematical models to predict its spread over large areas.
Contribution
The study introduces a novel homogenized model to describe thresholded transmission effects on large scales for chronic wasting disease.
Findings
Direct transmission leads to pulled fronts, while indirect transmission generates pushed fronts in CWD spread.
Pushed fronts allow CWD to spread even when infectives infect less than one susceptible on average.
The model predicts how habitat distribution influences CWD spread and mitigation.
Abstract
Thresholds in environmental transmission can significantly alter the dynamics of disease spread in wildlife. However, the impact of thresholds in landscapes with high spatial variability is not well understood. We investigate this phenomenon in chronic wasting disease (CWD), a degenerative cervid illness exhibiting direct transmission between individuals and indirect transmission through environmental hazard. The indirect pathway exhibits threshold behavior analogous to a strong Allee effect. We derive a partial differential equation (PDE) model for CWD on the scale of hours and tens of meters. Leveraging highly variable landscape structure, we homogenize this model to yield an asymptotically accurate approximal model on the scale of years and kilometers. Our homogenized model describes the aggregate effect of thresholded transmission on large scales – to our knowledge, the first time…
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Taxonomy
TopicsPrion Diseases and Protein Misfolding · Evolution and Genetic Dynamics · Animal Disease Management and Epidemiology