# Prevalence of symptomatic toxicities for novel therapies in adult oncology trials: a scoping review

## TL;DR

This review summarizes the common and less common symptoms caused by new cancer treatments like immunotherapy and targeted therapies, based on patient and clinical reports.

## Contribution

The study identifies key patient-reported toxicities for novel cancer therapies to guide future trial design and improve patient safety.

## Key findings

- Fatigue, diarrhea, and rash are the most commonly reported symptomatic adverse events across immunotherapy and targeted therapies.
- Less common but potentially harmful class-specific toxicities were also identified, emphasizing the need for better recognition and treatment.
- Many studies rely on clinician-reported data rather than patient self-reports for assessing toxicities.

## Abstract

Patients’ self-report of their symptoms can provide important data for the evaluation of treatment benefit and tolerability of oncology drugs. Contemporary treatment approaches, including immunotherapy and molecular targeted therapies, have unique toxicities based on their novel mechanisms of action. This scoping review aimed to summarize evidence from existing reviews and clinical practice guidelines to examine the type and prevalence of toxicities including symptomatic adverse events (sympAEs) for adult cancer patients to inform clinical care and therapeutic trials.

A systematic search of PubMed, Web of Science, and Embase was performed using predefined eligibility criteria. Thirty-one literature reviews and 3 clinical practice guidelines met inclusion criteria and were selected for review and data abstraction.

Findings from this scoping review demonstrated several leading sympAEs that were reported across immunotherapy and targeted therapy drugs, including fatigue, diarrhea, and rash. In addition to these more prevalent sympAEs, there were some less frequently reported class-specific sympAEs, which had potential for significant harm or disability to the patient if not properly identified and treated. Many studies reported toxicities as AEs or syndromes solely using data reported by clinicians without additional self-report from patients.

We identified several core sympAEs experienced by patients participating in oncology trials using immunotherapy and targeted therapy agents, which has implications for future trial design and drug labeling. Future cancer trials should assess patient-reported sympAEs based on the identified drug mechanism to inform the tolerability of these newer agents and enhance patient safety during trial participation and clinical care.