# Primary Clean Cell Renal Carcinoma Metastasis to the Gallbladder: A Case Report

**Authors:** Hao Fang, Yuwei Guo

PMC · DOI: 10.7759/cureus.82614 · 2025-04-20

## TL;DR

A rare case of kidney cancer spreading to the gallbladder highlights the need for careful diagnosis and monitoring in cancer survivors.

## Contribution

Reports a rare metastasis case of renal cell carcinoma to the gallbladder, emphasizing diagnostic challenges and clinical vigilance.

## Key findings

- RCC can metastasize to the gallbladder, a rare occurrence.
- Histopathology is essential to confirm metastasis and prevent misdiagnosis.
- Follow-up revealed new bone lesions, suggesting further metastatic spread.

## Abstract

Renal cell carcinoma (RCC) metastasis to the gallbladder is exceedingly rare. A 60-year-old man with a history of RCC underwent cholecystectomy for incidental gallbladder polyps. Pathology confirmed metastatic RCC via immunohistochemistry staining. Despite surgery, bone lesions suggestive of metastasis emerged at the eight-month follow-up. This case underscores the importance of vigilance for atypical metastases in RCC survivors and the critical role of histopathology in avoiding misdiagnosis.

## Linked entities

- **Diseases:** renal cell carcinoma (MONDO:0005086)

## Full-text entities

- **Diseases:** gallbladder polyps (MESH:D011127), Metastasis (MESH:D009362), bone lesions (MESH:D001847), Clean Cell Renal Carcinoma (MESH:D002292)

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12090143/full.md

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Source: https://tomesphere.com/paper/PMC12090143