Depth-dependent contributions of various vascular zones to cerebral autoregulation and functional hyperemia: An in-silico analysis
Hadi Esfandi, Mahshad Javidan, Rozalyn M. Anderson, Ramin Pashaie
TL;DR
This study uses a computational model to explore how different parts of the brain's blood vessels contribute to regulating blood flow at various depths.
Contribution
A novel computationally efficient model of mouse cerebrovasculature is introduced to analyze depth-dependent CBF regulation.
Findings
Small-diameter vessels like penetrating arterioles significantly control intravascular pressure and CBF.
Capillary diameter changes have minimal impact on functional hyperemia.
Hemodynamics show variability in transitional zone vessels but stability in capillaries across depths.
Abstract
Autoregulation and neurovascular coupling are key mechanisms that modulate myogenic tone (MT) in vessels to regulate cerebral blood flow (CBF) during resting state and periods of increased neural activity, respectively. To determine relative contributions of distinct vascular zones across different cortical depths in CBF regulation, we developed a simplified yet detailed and computationally efficient model of the mouse cerebrovasculature. The model integrates multiple simplifications and generalizations regarding vascular morphology, the hierarchical organization of mural cells, and potentiation/inhibition of MT in vessels. Our analysis showed that autoregulation is the result of the synergy between these factors, but achieving an optimal balance across all cortical depths and throughout the autoregulation range is a complex task. This complexity explains the non-uniformity observed…
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Taxonomy
TopicsTraumatic Brain Injury and Neurovascular Disturbances · Cerebrospinal fluid and hydrocephalus · Optical Imaging and Spectroscopy Techniques