# Anticipating Biopreservation Technologies that Pause Biological Time: Building Governance & Coordination Across Applications

**Authors:** Susan M. Wolf, Timothy L. Pruett, Claire Colby McVan, Evelyn Brister, Shawneequa L. Callier, Alexander M. Capron, James F. Childress, Michele Bratcher Goodwin, Insoo Hyun, Rosario Isasi, Andrew D. Maynard, Kenneth A. Oye, Paul B. Thompson, Terrence R. Tiersch

PMC · DOI: 10.1017/jme.2024.129 · 2025-05-19

## TL;DR

New biopreservation methods could pause biological time, enabling better storage of organs and tissues for medicine and conservation.

## Contribution

The paper introduces emerging biopreservation technologies and emphasizes the need for governance and coordination across their applications.

## Key findings

- Subzero biopreservation methods like supercooling and vitrification are advancing rapidly.
- These technologies could enable large-scale banking of biomedical products.
- Reanimating techniques such as nanoparticle infusion and laser rewarming are being developed.

## Abstract

Advanced biopreservation technologies using subzero approaches such as supercooling, partial freezing, and vitrification with reanimating techniques including nanoparticle infusion and laser rewarming are rapidly emerging as technologies with potential to radically disrupt biomedicine, research, aquaculture, and conservation. These technologies could pause biological time and facilitate large-scale banking of biomedical products including organs, tissues, and cell therapies.

## Full-text entities

- **Diseases:** trauma (MESH:D014947), deaths (MESH:D003643), genetic disorders (MESH:D030342), burn injuries (MESH:D002056), chromosomal abnormalities (MESH:D002869), inbreeding depression (MESH:D003866), cancer (MESH:D009369)
- **Chemicals:** ATP (MESH:D000255)
- **Species:** Danio rerio (leopard danio, species) [taxon 7955], Ovis aries (domestic sheep, species) [taxon 9940], Capra hircus (domestic goat, species) [taxon 9925], Cryptosporidium (genus) [taxon 5806], Felis catus (cat, species) [taxon 9685], Oryctolagus cuniculus (domestic rabbit, species) [taxon 9986], Homo sapiens (human, species) [taxon 9606], Rattus norvegicus (brown rat, species) [taxon 10116], Bos taurus (bovine, species) [taxon 9913], Equus caballus (domestic horse, species) [taxon 9796]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12087795/full.md

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Source: https://tomesphere.com/paper/PMC12087795