177Lu‐Gold Nanohybrids in Radiotherapeutic Approaches Against Cancer
Mathilde Ponchelle, Marek Pruszyński, Edmond Gravel, Eric Doris
TL;DR
This paper reviews how combining radioactive lutetium-177 with gold nanoparticles can enhance cancer radiotherapy by amplifying radiation effects in tumors.
Contribution
The paper provides a comprehensive review of 177Lu-gold nanohybrids for cancer therapy, highlighting design strategies and biological effects.
Findings
177Lu-gold nanohybrids amplify radiotoxicity in cancer cells through localized radiation enhancement.
In vitro and in vivo studies show these nanohybrids can selectively target and damage tumor tissue.
The paper identifies key factors influencing the effectiveness of 177Lu-gold systems in internal radiotherapy.
Abstract
Internal radionuclide therapy using lutetium‐177 (177Lu)‐based radiopharmaceuticals has emerged as a promising approach in the field of nuclear medicine and oncology. Combining the radioactive lanthanide with high atomic number metal nanoparticles such as gold potentiates the radiotoxicity of lutetium by an amplification process. 177Lu‐gold nanohybrids have been investigated by various research groups, both in vitro and in vivo, to decipher the physicochemical, radiochemical, and biological factors that would enable selective and optimal dose deposition in tumors. This review focuses on 177Lu‐gold tailored approaches that are developed in the literature to locally enhance internal radiotherapeutic effects. This article reviews the literature on nanoscale systems incorporating radioactive lutetium‐177 and gold nanoparticles as amplifying units, applied to internal radionuclide therapy…
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Taxonomy
TopicsRadiation Therapy and Dosimetry · Advanced Radiotherapy Techniques · Boron Compounds in Chemistry