# A rare case of a mammary analog secretory carcinoma of the right submandibular gland

## TL;DR

A rare case of mammary analog secretory carcinoma in a 64-year-old woman's submandibular gland was successfully treated with surgery and follow-up.

## Contribution

This paper reports a rare case of mammary analog secretory carcinoma in the submandibular gland, expanding the known spectrum of this tumor type.

## Key findings

- The patient had a submandibular gland tumor confirmed as mammary analog secretory carcinoma via histology and immunohistochemistry.
- The patient remained disease-free for 2 years following surgical excision and follow-up visits.
- The case highlights the importance of accurate diagnosis and tailored follow-up protocols for rare salivary gland tumors.

## Abstract

Salivary gland cancer is one of the most common malignant neoplasms of head and neck. Not only is it rare but its clinical course is also very heterogeneous. A 64-year-old woman was diagnosed with submandibular gland carcinoma. We performed an ultrasound examination and a magnetic resonance imaging of the head and neck, which revealed an oval expansive process in the right submandibular salivary gland, indicative of an aggressive neoplasm, such as adenocarcinoma. Surgical excision and histological examination were conducted reporting macroscopically a whitish nodular formation measuring 1.5 × 1 cm and microscopically positivity to cytokeratin 7 and mammaglobin, compatible with a mammary analog secretory carcinoma. No N positive since there is no clinical, instrumental, or laboratory evidence of the primary pathology. We just performed a surgical excision and accurate follow-up visits, and the patient has been free from disease for 2 years. Major efforts should be spent to establish the most adequate management and follow-up protocol visits.