# Mitral Valve Aneurysm With Severe Mitral Regurgitation and Pseudoaneurysm Formation: A Rare Complication of Infective Endocarditis

**Authors:** Kesar Prajapati, FNU Samaksh, Poornima Jaiswal Charpuria, Nisarg Desai, Ankit V Shah

PMC · DOI: 10.7759/cureus.82491 · Cureus · 2025-04-18

## TL;DR

A rare case of infective endocarditis leading to a mitral valve aneurysm and severe heart failure is reported, highlighting the need for early diagnosis and treatment.

## Contribution

This paper presents a rare clinical case of mitral valve aneurysm as a complication of infective endocarditis with fatal outcomes due to delayed diagnosis.

## Key findings

- A 34-year-old female with infective endocarditis developed a mitral valve aneurysm and pseudoaneurysm, leading to severe heart failure.
- Delayed diagnosis and advanced presentation resulted in refractory heart failure and electrical storm, causing a fatal outcome.
- The case emphasizes the importance of early recognition and timely surgical intervention for improved prognosis.

## Abstract

Infective endocarditis (IE) is a life-threatening condition caused by infection of the heart’s endocardial surface, often involving native or prosthetic valves. It presents with diverse symptoms, ranging from isolated fever and heart failure to more severe manifestations such as ischemic stroke from septic or thrombus embolization. A rare but serious complication of IE is mitral valve aneurysm (MVA), a localized outpouching of the mitral valve, often leading to mitral regurgitation (MR), heart failure, and, in severe cases, rupture. This report highlights a case of delayed diagnosis of IE in a 34-year-old female who presented with prolonged fever, progressive dyspnea, and signs of heart failure. Echocardiography revealed severe MR, anterior mitral valve leaflet perforation, and a large pseudoaneurysm, suggesting MVA. Because of the advanced presentation, the patient developed refractory heart failure and electrical storm, leading to a fatal outcome before surgery could be performed. This case underscores the importance of early recognition of IE and MVA and the challenges in managing complicated cases, where mitral valve replacement is the preferred surgical option. Early diagnosis and timely intervention are crucial to prevent severe complications and improve prognosis.

## Linked entities

- **Diseases:** infective endocarditis (MONDO:0000565), heart failure (MONDO:0005252)

## Full-text entities

- **Diseases:** IE (MESH:D004696), Pseudoaneurysm (MESH:D017541), rupture (MESH:D012421), dyspnea (MESH:D004417), ischemic stroke (MESH:D002544), thrombus (MESH:D013927), heart failure (MESH:D006333), infection (MESH:D007239), fever (MESH:D005334), MR (MESH:D008944)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

15 references — full list in the complete paper: https://tomesphere.com/paper/PMC12085972/full.md

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Source: https://tomesphere.com/paper/PMC12085972