# Study of Monocyte-High Density Lipoprotein ratio to coronary artery diameter in coronary heart disease patients

**Authors:** Azhari Gani, Muhammad Diah Yusuf, Siti Adewiyah, Malahayati

PMC · DOI: 10.21542/gcsp.2025.11 · Global Cardiology Science & Practice · 2025-02-28

## TL;DR

This study explores how the Monocyte to HDL ratio relates to coronary artery diameter in patients with coronary heart disease.

## Contribution

The study introduces MHR as a potential inexpensive and fast indicator for assessing coronary atherosclerosis severity.

## Key findings

- MHR was significantly correlated with coronary slow flow, MINOCA, and stenosis (p < 0.0001).
- Bivariate tests showed a relationship between MHR and coronary artery diameter in three groups.
- MHR could serve as a practical parameter for identifying atherosclerosis severity.

## Abstract

Background: The Monocyte to High-Density Lipoprotein Ratio (MHR) ratio reflects the proatherogenic and antiatherogenic balance and increased MHR values are related to coronary atherosclerosis obstruction’s presence, progressivity, and severity. This study uses medical records and coronary angiography data to assess the correlation between MHR and coronary artery diameter in coronary heart disease patients.

Methods: This study involved data from 230 patient medical records. The data collection approach was a cross-section design, and total sampling was performed by citing medical records of patients who underwent coronary angiography at the catheterization installation of Dr. Zainal Abidin Hospital, Banda Aceh, Indonesia.

Results: The multivariate test showed that MHR and the coronary slow flow group, MINOCA, and stenosis were significant with a value of p < 0.0001. The results of the bivariate test showed the relationship between MHR and coronary artery diameter in all three groups. Coronary slow flow, MINOCA, and stenosis were insignificant p > 0.05.

Conclusion: This study shows that MHR can be a suitable, inexpensive, fast parameter for identifying the severity of coronary atherosclerosis obstruction.

## Linked entities

- **Diseases:** coronary heart disease (MONDO:0005010), coronary atherosclerosis (MONDO:0021661)

## Full-text entities

- **Diseases:** coronary heart disease (MESH:D003327), coronary atherosclerosis obstruction (MESH:D003324), stenosis (MESH:D003251)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12085926/full.md

## References

39 references — full list in the complete paper: https://tomesphere.com/paper/PMC12085926/full.md

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Source: https://tomesphere.com/paper/PMC12085926