# Whole-body MRI for a patient with progressive multiple myeloma

## TL;DR

This paper discusses how whole-body MRI can better detect early signs of multiple myeloma compared to other imaging methods.

## Contribution

The paper highlights the unique value of whole-body MRI in detecting early disease changes in a progressive multiple myeloma case.

## Key findings

- Whole-body MRI detects disease before cortical and trabecular bone changes occur.
- Whole-body MRI provides more insight than plain films and CT in assessing disease extent.
- Combining imaging with traditional monitoring improves disease burden assessment.

## Abstract

Multiple Myeloma represents a plasma cell disorder that can result in hallmark bony destructive change in addition to other signs of myelomatous disease. Imaging often helps in establishing the diagnosis and staging the patient. There are several different imaging modalities that can provide different levels of insight into the disease extent. We report a unique case of multiple myeloma where the progressive nature of the patient’s disease highlights the strengths and limitations of the different imaging approaches. Whole-body MRI represents a noncontrast imaging technique that directly images the bone marrow space, allowing for disease detection that can precede the onset of cortical and trabecular destructive changes. In so doing, whole-body MRI provides a level of insight that far exceeds traditional plain films and even CT. Using the findings from many different imaging modalities (plain films, CT, PET-CT, and whole-body magnetic resonance imaging), we will discuss how imaging can help clinicians to better assess the patient’s disease burden and complement the foundations of traditional disease monitoring (serology, histopathology from biopsy, direct clinical exam, and observation).