# Presentation of an unusual variant of cellular dermatofibroma: a case report

**Authors:** Basem H Alshareef, Ghadeer Faiz M Alharthi, Saleha Khan, Shumaila Baig

PMC · DOI: 10.1093/jscr/rjaf257 · Journal of Surgical Case Reports · 2025-05-17

## TL;DR

This case report describes a rare form of dermatofibroma that initially appeared as a foot ulcer and was mistaken for a more serious tumor.

## Contribution

The paper presents a unique clinical case of cellular dermatofibroma with diagnostic challenges resembling sarcoma.

## Key findings

- A 26-year-old female presented with a painless foot ulcer diagnosed as cellular dermatofibroma after excision.
- Cellular DF can mimic aggressive tumors like sarcoma, requiring histopathological confirmation for accurate diagnosis.

## Abstract

Dermatofibromas (DF), also known as cutaneous fibrous histiocytomas, are benign soft-tissue tumours that are typically asymptomatic. These lesions most commonly appear on the distal extremities and are frequently seen in young to middle-aged individuals. Diagnosis is primarily based on histopathological examination, which generally aligns with radiological findings. This report highlights an atypical variant of cellular DF, in a 26-year-old female who presented with a painless foot ulcer on her lower leg. Initially, the lesion was suspected to be a sarcoma. After excision, the diagnosis was confirmed through histopathological analysis. Cellular DF are challenging to diagnose as they can mimic more aggressive tumours, such as malignant fibrous histiocytomas or dermatofibrosarcoma protuberans. While DF are common, their atypical variants, like cellular dermatofibroma, can complicate diagnosis and require timely diagnosis and effective management.

## Linked entities

- **Diseases:** sarcoma (MONDO:0005089), malignant fibrous histiocytoma (MONDO:0002142), dermatofibrosarcoma protuberans (MONDO:0011934)

## Full-text entities

- **Diseases:** dermatofibrosarcoma protuberans (MESH:D018223), benign soft-tissue tumours (MESH:D012983), sarcoma (MESH:D012509), DF (MESH:D018219), malignant fibrous histiocytomas (MESH:D051677), foot ulcer (MESH:D016523), tumours (MESH:D009369)

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12085192/full.md

## References

13 references — full list in the complete paper: https://tomesphere.com/paper/PMC12085192/full.md

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Source: https://tomesphere.com/paper/PMC12085192