# Changes in tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6), matrix metallopeptidase-2/9 (MMP-2/9), and T-lymphocyte subsets in patients undergoing thoracoscopic surgery under refined management for non-small-cell lung cancer

## TL;DR

This study examines how refined care during thoracoscopic surgery for lung cancer affects immune responses and psychological outcomes in patients.

## Contribution

The study shows that refined perioperative care improves immune function and psychological status in NSCLC patients.

## Key findings

- The research group had lower postoperative inflammatory factors and CD8+ levels compared to the control group.
- CD3+, CD4+, and CD4+/CD8+ levels were higher in the research group, indicating improved immune function.
- There was no significant difference in survival rates between the two groups over six months.

## Abstract

Non-small-cell lung cancer (NSCLC) remains one of the most common malignancies worldwide, posing a great potential threat to the health and life safety of patients.

One hundred and fifty NSCLC patients admitted to our hospital from September 2022 to September 2023 were selected whose inflammatory response and changes in T-lymphocyte subpopulations before and after surgery were detected, and patients' psychological status was investigated. Finally, patients were followed up for 6 months to record the prognostic survival rate.

Postoperative inflammatory factors and CD8 + were lower in the research group than in the control group, while CD3 + , CD4 + and CD4 + /CD8 + were higher than in the control group (P<0.05). Meanwhile, the psychological status of the research group was better. However, the two groups did not differ in prognostic survival (P>0.05).

Perioperative refinement of care can optimize the surgical process in patients with NSCLC, and the cellular immune function was enhanced.