# Effect of glycemic gap on prognosis and complications in vulnerable period of acute heart failure

## TL;DR

This study finds that a larger glycemic gap in patients with acute heart failure is linked to worse outcomes and more complications.

## Contribution

The study identifies the glycemic gap as an independent predictor of prognosis and complications in acute heart failure patients.

## Key findings

- Patients with good prognosis had lower glycemic gaps and better heart function markers compared to those with poor prognosis.
- Glycemic gap was an independent influencing factor for prognosis in acute heart failure patients.
- The good prognosis group had significantly fewer complications compared to the poor prognosis group.

## Abstract

To investigate the effect of glycemic gap on the prognosis and complications of heart failure in patients with acute heart failure.

A total of 100 patients with acute heart failure admitted to our hospital from January 2022 to August 2023 were retrospectively selected, and the patients were divided into two groups according to their prognosis, the good prognosis group (n=58) and the poor prognosis group (n=42). The general data of the two groups were compared, and the influencing factors on the prognosis of patients with acute heart failure during the fragile period were analyzed by multi-factor Logistics regression. ROC analyzed the predictive value of blood sugar gap on the prognosis of acute heart failure patients during the vulnerable period of heart failure, and compared the incidence of complications between the two groups of patients..

The blood glucose gap, NT-proBNP, Ang II, hscTn, and SCR in patients with good prognosis were lower than those in patients with poor prognosis, and LVEF and hemoglobin were higher than those in patients with poor prognosis (P<0.05). Multivariate Logistics regression analysis results showed that blood glucose gap, NTproBNP, AngII, hs-cTn, SCR, LVEF, and hemoglobin were independent influencing factors on the prognosis of acute heart failure patients during the vulnerable period of heart failure (P<0.05), ROC analysis results showed that the area under the curve of the value of blood sugar gap in the prognosis of acute heart failure patients during the vulnerable period of heart failure was 0.6071,(95% CI: 0.3107~0.9035), Youden=0.89, at this time, the sensitiv ity was 92.8 and the specificity was 97.1. The complication rate in the good prognosis group (1.72%) was significantly lower than that in the poor prognosis group (16.67%).

Glycemic gap is related to the prognosis and complications of heart failure in patients with acute heart failure. Hyperglycemia gap will affect the prognosis of heart failure in patients with acute heart failure, resulting in poor prognosis and increasing the incidence of complications.