# Leukemia Cutis With Concomitant Seborrheic Keratosis as the Presenting Symptom of Chronic Lymphocytic Leukemia: A Case Report

## TL;DR

A rare case of leukemia cutis presented with a skin lesion and seborrheic keratosis, later diagnosed as chronic lymphocytic leukemia with a favorable prognosis.

## Contribution

This case report highlights an unusual presentation of chronic lymphocytic leukemia with concomitant seborrheic keratosis.

## Key findings

- A biopsy showed seborrheic keratosis in the epidermis and lymphoid infiltration in the dermis.
- Flow cytometry confirmed B-cell chronic lymphocytic leukemia with a chromosomal deletion at 13q14.
- The patient was monitored without pharmacologic treatment due to a favorable prognosis.

## Abstract

Leukemia cutis is a term used to describe a dermatologic manifestation of hematologic malignancies. It represents a wide range of identifiable cutaneous lesions that result from the infiltration of neoplastic leukocytes in patients with leukemia or lymphoma. We report a case involving an initial solitary lesion without systemic symptoms, but a biopsy revealed a seborrheic keratosis in the epidermis with lymphoid infiltration in the dermis. Flow cytometry studies confirmed a B-cell chronic lymphocytic leukemia, and an additional investigation with fluorescence in situ hybridization demonstrated a chromosomal deletion in the long arm of chromosome 13 at position 14, indicating a favorable prognosis. The patient was referred to a hematologist, who determined that no pharmacologic treatment was necessary at that time. The patient continues to follow up for monitoring of his disease.