# Three Synchronous Pituitary Neuroendocrine Tumors—Epigenomics Confirm an Exceptional Triple PitNET

**Authors:** Temor Rafiq, Jakob Matschke, Jörg Flitsch, Matthias Dottermusch

PMC · DOI: 10.1007/s12022-025-09864-1 · Endocrine Pathology · 2025-05-16

## Full-text entities

- **Genes:** GH1 (growth hormone 1) [NCBI Gene 2688] {aka GH, GH-N, GHB5, GHN, IGHD1A, IGHD1B}, POU1F1 (POU class 1 homeobox 1) [NCBI Gene 5449] {aka CPHD1, GHF-1, PIT1, POU1F1a, Pit-1}, SF1 (splicing factor 1) [NCBI Gene 7536] {aka BBP, D11S636, MBBP, ZCCHC25, ZFM1, ZNF162}, GGH (gamma-glutamyl hydrolase) [NCBI Gene 8836] {aka GATD10, GH}, POMC (proopiomelanocortin) [NCBI Gene 5443] {aka ACTH, CLIP, LPH, MSH, NPP, OBAIRH}, TBX19 (T-box transcription factor 19) [NCBI Gene 9095] {aka TBS19, TPIT, dJ747L4.1}, PRL (prolactin) [NCBI Gene 5617] {aka GHA1, pPRL}, STH (saitohin) [NCBI Gene 246744] {aka MAPTIT}, CMM (cutaneous malignant melanoma/dysplastic nevus) [NCBI Gene 1243] {aka CMM1, DNS, FAMMM, MLM}, SFTPA2 (surfactant protein A2) [NCBI Gene 729238] {aka COLEC5, ILD2, PSAP, PSP-A, PSPA, SFTP1}
- **Diseases:** pituitary insufficiency (MESH:D007018), pituitary (MESH:D010900), pituitary adenoma (MESH:D010911), neurological deficit (MESH:D009461), pituitary mass (MESH:C536030), brain tumor (MESH:D001932), malignant melanoma (MESH:D008545), tumor (MESH:D009369), PitNETs (MESH:D018358), hypophysitis (MESH:D000072659)
- **Chemicals:** H&E (MESH:D006371), Hematoxylin (MESH:D006416), eosin (MESH:D004801)
- **Species:** Homo sapiens (human, species) [taxon 9606]

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Source: https://tomesphere.com/paper/PMC12084165