# Community-engaged adaptation and pilot testing of a mental health and substance use screening and referral process in HIV pre-exposure prophylaxis (PrEP) care in the Southern USA

**Authors:** Susan Reif, Sarah M. Wilson, Elena Wilson, Haley Cooper, Andy Weinhold, Amy Corneli

PMC · DOI: 10.1371/journal.pmen.0000148 · PLOS mental health · 2025-05-16

## TL;DR

This paper describes adapting a mental health and substance use screening model for use in PrEP care, finding it acceptable and valued by patients and staff.

## Contribution

The novel contribution is adapting and pilot testing the SBIRT model for mental health screening in PrEP care for SGLBM in the Southern USA.

## Key findings

- The adapted SBIRT PrEP model was found acceptable and valued by clinic clients and staff.
- Most clients believed the screening was appropriate and important for PrEP services.
- Clients felt comfortable using the iPad for screening and discussing results with a navigator.

## Abstract

Mental health and substance use concerns are prevalent in HIV pre-exposure prophylaxis (PrEP)-seeking and priority populations (e.g., same gender loving black men (SGLBM)), often negatively affecting health care outcomes. Identifying individuals who could benefit from access to effective behavioral health treatment remains suboptimal among these populations. We utilized a community-informed process to adapt an evidence-based behavioral health identification and linkage model, Screening Brief Intervention and Referral to Treatment (SBIRT), to include mental health screening and increase cultural responsiveness for use in PrEP care. We piloted the adapted SBIRT model (SBIRT PrEP) in a PrEP clinic in the U.S. South that serves primarily SGLBM. A total of 29 SGLBM participated in the pilot, which involved answering screening questions about anxiety, depression, alcohol, and drug use on an iPad. Participants met with a PrEP navigator to review screening results using a guided model that incorporated participant self-determination and motivational interviewing techniques. SGLBM and staff completed surveys and qualitative interviews that assessed their perceptions of the program. Study findings indicated that the adapted SBIRT PrEP model was acceptable and valued by clinic clients and staff. Survey and interview responses indicated that most clients believed that: 1) substance use and mental health screening was appropriate and important to include in PrEP services; 2) the program was an effective way to address mental health and substance use concerns; and 3) the duration of the screening process was acceptable. A majority of clients reported feeling comfortable answering behavior health screening questions on the iPad and discussing the results with the PrEP navigator. A larger, more rigorous trial is needed to further test the SBIRT PrEP model. Identifying methods to better address behavioral health concerns is critical to enhance PrEP participation and improve quality of life for individuals receiving PrEP.

## Full-text entities

- **Genes:** GAD1 (glutamate decarboxylase 1) [NCBI Gene 2571] {aka CPSQ1, DEE89, GAD, GAD-67, SCP}
- **Diseases:** mental illness (MESH:D001523), Alcohol Use Disorders (MESH:D000437), Generalized Anxiety Disorder (MESH:C000726808), SSI (MESH:D020914), Substance Abuse (MESH:D019966), depression (MESH:D003866), marijuana (MESH:D000074609), anxiety (MESH:D001007), Mental (MESH:D008607), Mental health (OMIM:603663), HIV (MESH:D015658)
- **Chemicals:** substance (MESH:C012600), Cannabis Use Disorder (-), alcohol (MESH:D000438)
- **Species:** Homo sapiens (human, species) [taxon 9606], Human immunodeficiency virus 1 (no rank) [taxon 11676], Nicotiana tabacum (American tobacco, species) [taxon 4097]

## Full text

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## References

40 references — full list in the complete paper: https://tomesphere.com/paper/PMC12083854/full.md

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Source: https://tomesphere.com/paper/PMC12083854