# Outpatient care changes and associated mortality among Veterans with heart failure during the COVID-19 pandemic

**Authors:** Shilpa Vijayakumar, Emily Corneau, Sebhat Erqou, Aravind Kokkirala, Wen-Chih Wu, Pracheth Raghuveer, Pracheth Raghuveer, Pracheth Raghuveer, Pracheth Raghuveer, Pracheth Raghuveer

PMC · DOI: 10.1371/journal.pone.0323308 · PLOS One · 2025-05-16

## TL;DR

During the pandemic, Veterans with heart failure had fewer outpatient visits, and those who had in-person visits had lower mortality risk compared to those with no visits.

## Contribution

Quantified the impact of reduced in-person outpatient care and increased virtual visits on mortality in heart failure patients during the pandemic.

## Key findings

- Outpatient visits for heart failure patients decreased significantly during the pandemic despite increased use of virtual care.
- In-person visits were associated with the lowest mortality risk compared to video-only or telephone-only visits.
- The mortality risk was higher for patients with no outpatient visits compared to those who had any form of visit.

## Abstract

The mortality risk associated with loss of in-person outpatient visits or transition to virtual care in patients with heart failure (HF) during the COVID-19 pandemic is unknown.

Assess changes in outpatient HF care patterns and associated mortality.

Retrospective analysis of HF patients using national Veterans-Health-Administration (VHA) data. Among 509,511 HF patients who received VHA care, we compared mean monthly days-with-an-outpatient-visit from 2/2018–1/2020 (pre-COVID) versus 2/2020–1/2021 (COVID) using T-tests. In a subset of 321,439 patients with ≥1 VHA cardiology or primary-care visit in 2019, we related the presence and type of outpatient visit with mortality using Cox-Regression estimated hazard-ratios (HRs).

Despite a 2–3-fold increase in video-only visits and use of telephone visits to maintain access, the overall days with outpatient visits decreased from a monthly-average of 81.4 ± 6.1 in 2018–2019 and 81.0 ± 5.6 in 2019–2020, to 57.8 ± 11 days in 2020–2021 (P < 0.01 for both), per 100 Veterans. When compared to patients with no-visits during the study period, the adjusted-mortality risk was lowest for patients with at least one in-person (HR 0.42, 95%CI: 0.41–0.44), followed by video-only (HR 0.52, 95%CI: 0.50–0.55) and then telephone-only (HR 0.57, 95%CI: 0.54–0.60) visits (p = 0.14 for trend). Results remained similar when the analysis was repeated (without including telephone visits) for pre-COVID (2/2018–1/2020) periods.

Despite an increase in video and use of telephone visits during the COVID-19 pandemic, there was still a decrease in total outpatient visits for patients with HF. The presence and type of outpatient encounter was associated with the adjusted risk of mortality.

## Linked entities

- **Diseases:** heart failure (MONDO:0005252)

## Full-text entities

- **Genes:** INS (insulin) [NCBI Gene 3630] {aka IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10}, COX8A (cytochrome c oxidase subunit 8A) [NCBI Gene 1351] {aka COX, COX8, COX8-2, COX8L, MC4DN15, VIII}, NPPB (natriuretic peptide B) [NCBI Gene 4879] {aka BNP, Iso-ANP}
- **Diseases:** diabetes (MESH:D003920), other (MESH:D058497), COVID (MESH:D000086382), Pulmonary Circulation Disease (MESH:D008171), end stage renal disease (MESH:D007676), aneurysm of pulmonary artery (MESH:D000071079), arteriovenous fistula of pulmonary vessels (MESH:C562404), Death (MESH:D003643), hypertension (MESH:D006973), cancer (MESH:D009369), atherosclerotic heart disease (MESH:D006331), Eisenmenger's syndrome (MESH:D004541), HF (MESH:D006333), chronic pulmonary embolism (MESH:D011655), respiratory illness (MESH:D012140), Amyloidosis (MESH:D000686), chronic pulmonary disease (MESH:D002908), Hypertensive chronic kidney disease (MESH:D051436), Renal Failure (MESH:D051437), secondary pulmonary arterial hypertension (MESH:D000081029), COPD (MESH:D029424), cor pulmonale (MESH:D011660), frailty (MESH:D000073496), hypoxia (MESH:D000860), cardiovascular diseases (MESH:D002318), pulmonary Vascular Disease (MESH:D014652), primary pulmonary hypertension (MESH:D006976)
- **Chemicals:** NO (MESH:D009614), NT-proBNP (-), -D (MESH:D003903)
- **Species:** Severe acute respiratory syndrome coronavirus 2 (no rank) [taxon 2697049], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

24 references — full list in the complete paper: https://tomesphere.com/paper/PMC12083836/full.md

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Source: https://tomesphere.com/paper/PMC12083836