# Segmental Vitiligo: Rapid Spread From a Halo Nevus

**Authors:** Monica Z Trevino, Jodie Shao, Elene Valladares, Dale Quest

PMC · DOI: 10.7759/cureus.82378 · Cureus · 2025-04-16

## TL;DR

This paper reports a rare case of segmental vitiligo developing from a halo nevus in a teenager, highlighting its distinct unilateral pattern and lack of autoimmune comorbidities.

## Contribution

The paper presents a rare clinical case linking a halo nevus to segmental vitiligo, emphasizing its unique characteristics and implications for diagnosis.

## Key findings

- The depigmentation followed Blaschko’s lines and halted at the midline, typical of segmental vitiligo.
- The patient showed no autoimmune comorbidities, aligning with the segmental vitiligo pattern.
- Recent guidelines suggest topical calcineurin or JAK/STAT inhibitors as first-line treatments.

## Abstract

Vitiligo, a skin condition characterized by depigmentation, is classified into segmental and non-segmental forms based on onset and distribution. While halo nevi typically accompany non-segmental vitiligo, this report documents a rare case where a halo nevus transitioned into segmental vitiligo in an adolescent male. The depigmentation exhibited a distinct unilateral pattern, halting at the midline, which is characteristic of segmental vitiligo. Unlike non-segmental vitiligo, segmental vitiligo is less commonly associated with autoimmune diseases, and this patient's lack of autoimmune comorbidity aligns with that pattern. The depigmentation followed Blaschko’s lines, which typically do not cross the midline. Based on the consultation at the time, no immediate treatment was recommended. Recent guidelines suggest first-line use of topical calcineurin inhibitors like tacrolimus or JAK/STAT inhibitors like ruxolitinib. Understanding diverse vitiligo presentations is crucial for more precise diagnosis and treatment strategies.

## Linked entities

- **Chemicals:** tacrolimus (PubChem CID 445643), ruxolitinib (PubChem CID 17754772)
- **Diseases:** vitiligo (MONDO:0008661)

## Full-text entities

- **Diseases:** skin condition (MESH:D012871), Halo Nevus (MESH:D055882), autoimmune diseases (MESH:D001327), Vitiligo (MESH:D014820)
- **Chemicals:** ruxolitinib (MESH:C540383), tacrolimus (MESH:D016559)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12083554/full.md

## References

18 references — full list in the complete paper: https://tomesphere.com/paper/PMC12083554/full.md

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Source: https://tomesphere.com/paper/PMC12083554