# Chronic Pancreatitis and Pancreas Divisum: A Case Report of Recurrent Management Challenges

**Authors:** Shivangini Duggal, Ozioma Akahara, Claudia Didia

PMC · DOI: 10.7759/cureus.82313 · Cureus · 2025-04-15

## TL;DR

A 46-year-old man with chronic pancreatitis due to pancreas divisum faced multiple hospitalizations before diagnosis, highlighting the need for early detection of congenital pancreatic anomalies.

## Contribution

This case emphasizes the importance of considering pancreas divisum in recurrent pancreatitis and the value of systematic diagnostic approaches.

## Key findings

- Pancreas divisum can cause chronic pancreatitis and is often misdiagnosed due to its subtle presentation.
- Non-invasive imaging like MRI is preferred for initial diagnosis, while endoscopic treatment is typically effective.
- Early recognition of congenital anomalies can prevent unnecessary interventions and delays in treatment.

## Abstract

Pancreas divisum, resulting from incomplete fusion of the pancreatic ducts during development, disrupts normal drainage and can lead to recurrent acute and chronic pancreatitis. This report presents a case of a 46-year-old male with chronic necrotizing pancreatitis secondary to pancreas divisum. The patient experienced multiple hospital admissions and underwent a cholecystectomy before the underlying etiology, pancreas divisum, was identified after six hospitalizations. This case highlights the diagnostic challenges of recurrent pancreatitis, emphasizing the importance of considering congenital pancreatic anomalies in patients with unexplained or refractory disease. It also underscores the need for a systematic approach to evaluating recurrent pancreatitis to avoid delays in diagnosis and unnecessary interventions. Pancreas divisum is associated with recurrent pancreatitis in a subset of patients. While endoscopic retrograde cholangiopancreatography remains the gold standard for diagnosis and intervention, non-invasive imaging such as magnetic resonance cholangiopancreatography is preferred for initial diagnosis. Endoscopic treatment, including minor papilla papillotomy and stenting, is typically effective for symptomatic cases. However, surgery may be necessary when these methods fail.

## Linked entities

- **Diseases:** chronic pancreatitis (MONDO:0005003), acute pancreatitis (MONDO:0006515)

## Full-text entities

- **Genes:** PRSS1 (serine protease 1) [NCBI Gene 5644] {aka TRP1, TRY1, TRY4, TRYP1}, GPT (glutamic--pyruvic transaminase) [NCBI Gene 2875] {aka AAT1, ALT, ALT1, GPT1, SGPT}, SLC17A5 (solute carrier family 17 member 5) [NCBI Gene 26503] {aka AST, ISSD, NSD, SD, SIALIN, SIASD}, CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}, CFTR (CF transmembrane conductance regulator) [NCBI Gene 1080] {aka ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR}, SCT (secretin) [NCBI Gene 6343]
- **Diseases:** Chronic Pancreatitis (MESH:D050500), sphincter of Oddi dysfunction (MESH:D046628), necrotizing pancreatitis (MESH:D019283), hyperphosphatemia (MESH:D054559), stone (MESH:D007669), pancreatic pseudocyst (MESH:D010192), shortness of breath (MESH:D004417), acute and chronic pancreatitis (MESH:D010195), hemorrhage (MESH:D006470), hyperparathyroidism (MESH:D006961), hyperglycemia (MESH:D006943), edema (MESH:D004487), hypokalemia (MESH:D007008), hypercalcemia (MESH:D006934), common bile duct stricture (MESH:D003137), tenderness (MESH:D063806), acidosis (MESH:D000138), emesis (MESH:D014839), Pancreas (MESH:D010190), gallstones (MESH:D042882), ileus (MESH:D045823), necrosis (MESH:D009336), small bowel obstruction (MESH:D007409), anatomical (MESH:D020763), Pancreas Divisum (MESH:D000092142), cough (MESH:D003371), pancreatic ductal dilation (MESH:D021441), ductal anomalies (MESH:D044584), autoimmune conditions (MESH:D001327), abdominal pain (MESH:D015746), hypertriglyceridemia (MESH:D015228), tachypnea (MESH:D059246), infection (MESH:D007239), epigastric pain (MESH:D010146), hypertensive (MESH:D006973), Inflammatory (MESH:D007249), nausea (MESH:D009325)
- **Chemicals:** AXIOS (-), ondansetron (MESH:D017294), oxygen (MESH:D010100), hydrocodone (MESH:D006853), acetaminophen (MESH:D000082), morphine (MESH:D009020), alcohol (MESH:D000438)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Mutations:** A1C

## Full text

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## Figures

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## References

19 references — full list in the complete paper: https://tomesphere.com/paper/PMC12080951/full.md

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Source: https://tomesphere.com/paper/PMC12080951