# Heterotopic adrenal tissue in a specimen after unilateral salpingo-oophorectomy: a case report

**Authors:** Dominika Trojnarska, Ewa Zabiegło, Robert Jach

PMC · DOI: 10.1186/s13256-025-05290-3 · Journal of Medical Case Reports · 2025-05-14

## TL;DR

A rare case of heterotopic adrenal tissue was found in a perimenopausal woman during a routine surgical procedure.

## Contribution

This report highlights the unusual occurrence of heterotopic adrenal tissue in an adult woman.

## Key findings

- Heterotopic adrenal tissue was incidentally discovered in a 54-year-old woman during a salpingo-oophorectomy.
- The patient remained asymptomatic and showed no complications following the procedure.
- Literature review confirmed the rarity of such findings in adult females.

## Abstract

Heterotopic adrenal tissue is an extremely rare finding. The most common site is the genitourinary tract and pelvis, more frequently in male than female children. In our report, we discuss an ectopic adrenal tissue detected incidentally in a perimenopausal woman, which is even more unusual.

A 54-year-old Eastern European perimenopausal female patient was referred for surgical treatment due to a suspected 60 mm paratubal cyst. Her medical history was unremarkable and risk of ovarian malignancy algorithm score were normal. Laparoscopic left salpingo-oophorectomy was performed and the specimen was sent for histopathology. The examination revealed a normal ovary, a fallopian tube with a simple paratubal cyst, and a 2.5 mm nest of heterotopic adrenal tissue in the nearby fat tissue. The patient was discharged on the first postoperative day, reported no symptoms, and remained asymptomatic at 3-week follow-up.

A review of the available English literature confirmed the rarity of heterotopic adrenal tissue in adult women. This case is presented due to its uniqueness, with the aim of raising awareness about the entity we encountered and presenting its possible implications.

## Full-text entities

- **Genes:** POMC (proopiomelanocortin) [NCBI Gene 5443] {aka ACTH, CLIP, LPH, MSH, NPP, OBAIRH}
- **Diseases:** ectopic adrenal rest (MESH:D000314), Heterotopic (MESH:D063192), tissue (MESH:D017695), Cushing's disease (MESH:D047748), clear cell renal cell carcinoma (MESH:D002292), hypertension (MESH:D006973), hypercholesterolemia (MESH:D006937), Sertoli-Leydig cell tumor (MESH:D018310), carcinomas (MESH:D009369), adenomas (MESH:D000236), Cushing's syndrome (MESH:D003480), glucose intolerance (MESH:D018149), Nelson's syndrome (MESH:D009347), ectopic adrenal tissue (MESH:D002828), congenital adrenal hyperplasia (MESH:D000312), ectopic (MESH:C566852), fasciotruncal obesity (MESH:D009765), ovarian malignancy (MESH:D010051), adrenal insufficiency (MESH:D000309), paratubal cyst (MESH:D010310), hyperplastic ectopic adrenal glands (MESH:D000307), Adrenal ectopia (MESH:C563268), bleeding (MESH:D006470), adrenal cortical carcinoma (MESH:D018268)
- **Chemicals:** potassium (MESH:D011188), aldosterone (MESH:D000450), cortisol (MESH:D006854), 17-Hydroxyprogesterone (MESH:D019326), DHEAS (MESH:D019314), sodium (MESH:D012964)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

4 references — full list in the complete paper: https://tomesphere.com/paper/PMC12080163/full.md

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Source: https://tomesphere.com/paper/PMC12080163