# Post‐COVID‐Syndrome Patients Might Overestimate Own Cognitive Impairment

**Authors:** Sofia Wöhrstein, Tamara Matuz, Lilli Rötzer, Hans‐Otto Karnath

PMC · DOI: 10.1111/ene.70195 · European Journal of Neurology · 2025-05-15

## TL;DR

Post-COVID patients often report cognitive issues, but these rarely match objective tests, possibly due to depression.

## Contribution

This study reveals a low correlation between subjective cognitive complaints and objective impairment in Post-COVID Syndrome patients.

## Key findings

- Only 4% to 40% of subjective cognitive complaints matched objective cognitive deficits.
- Depressive symptoms may explain the mismatch between perceived and actual cognitive impairment.

## Abstract

After a COVID‐19 infection, some patients experience long‐term consequences known as Post‐Covid Syndrome, which often includes cognitive impairment. We investigated the congruence between subjectively experienced and objectively measured cognitive deficits after a COVID‐19 infection in an unselected, successively admitted cohort of 46 patients reporting subjective cognitive complaints (SCC).

We employed a comprehensive neuropsychological test battery to assess objective cognitive impairment across various cognitive domains. Three different cut‐off criteria were applied, commonly used in the literature to define objective neurocognitive disorder (NCD).

We observed a notably low congruence between SCC and NCD in Post‐Covid Syndrome, regardless of the cut‐off criterion. Depending on the cognitive domain, only 4% to maximally 40% of the SCC could be objectified.

One possible explanation for this discrepancy could be the high rate of depressive symptoms observed in the group of patients studied, which may negatively influence the perception of one's cognitive abilities. These findings emphasize the need for careful evaluation of SCC in Post‐Covid Syndrome and suggest that treating depressive symptoms may also alleviate some of the perceived cognitive deficits.

## Full-text entities

- **Genes:** PGR (progesterone receptor) [NCBI Gene 5241] {aka NR3C3, PR}
- **Diseases:** Mental Disorders (MESH:D001523), brain fog (MESH:D005222), rapid exhaustion (MESH:D006359), endothelial dysfunction (MESH:D014652), headache (MESH:D006261), deficit (MESH:D009461), fatigue (MESH:D005221), traumatic brain injury (MESH:D000070642), NCD (MESH:D019965), deficits in attention, memory, and executive functioning (MESH:D001289), COVID-19 long-term effects (MESH:D000094024), Cognitive Impairment (MESH:D003072), insomnia (MESH:D007319), infected (MESH:D007239), autoimmunity (MESH:D001327), Depression (MESH:D003866), immune dysregulation (OMIM:614878), chronic inflammation (MESH:D007249), deficits in Visual Reproduction (MESH:D014786), COVID-19 Infections (MESH:D000086382), anxiety (MESH:D001007)
- **Species:** Homo sapiens (human, species) [taxon 9606], Severe acute respiratory syndrome coronavirus 2 (no rank) [taxon 2697049]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12079761/full.md

## References

55 references — full list in the complete paper: https://tomesphere.com/paper/PMC12079761/full.md

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Source: https://tomesphere.com/paper/PMC12079761