# Non-functioning pancreatic neuroendocrine tumor presenting with acute pancreatitis: a case report

**Authors:** Aref Al-Rajabi, Amal A Thweib, Natalia M Daghlis, Howaida A Rabba, Nameer AbuMunshar, Abdel Majeed Al Ali, Izzeddin A Bakri

PMC · DOI: 10.1093/omcr/omae207 · Oxford Medical Case Reports · 2025-03-20

## TL;DR

A 34-year-old man with a rare non-functioning pancreatic tumor experienced recurring acute pancreatitis, leading to a successful surgical treatment.

## Contribution

This case report presents a rare presentation of a non-functioning pancreatic neuroendocrine tumor causing acute pancreatitis.

## Key findings

- The patient had a grade 1 neuroendocrine tumor confirmed via biopsy.
- The tumor's location near the pancreatic head necessitated a Whipple procedure.
- The case underscores the rarity of pNETs presenting with acute pancreatitis.

## Abstract

Pancreatic neuroendocrine tumors (pNETs) are a group of tumors with complex therapeutic options that differ according to pathological grading, clinical staging, and the existence of hormone secretion symptoms. We report a 34-year-old male with recurrent acute pancreatitis due to a non-functioning pNET. He presented with intermittent epigastric pain and elevated pancreatic enzymes. MRCP and endoscopic ultrasound revealed an oval lesion near the pancreatic head, confirmed as a grade 1 neuroendocrine tumor on biopsy. A Whipple procedure was performed based on tumor size and location. This case highlights the rare occurrence of pNET presenting with acute pancreatitis.

## Linked entities

- **Diseases:** acute pancreatitis (MONDO:0006515), pancreatic neuroendocrine tumor (MONDO:0019954)

## Full-text entities

- **Genes:** ADA2 (adenosine deaminase 2) [NCBI Gene 51816] {aka ADGF, CECR1, IDGFL, PAN, SNEDS, VAIHS}, DES (desmin) [NCBI Gene 1674] {aka CDCD3, CSM1, CSM2, LGMD1D, LGMD1E, LGMD2R}, MUC1 (mucin 1, cell surface associated) [NCBI Gene 4582] {aka ADMCKD, ADMCKD1, ADTKD2, CA 15-3, CD227, Ca15-3}
- **Diseases:** cholelithiasis (MESH:D002769), exocrine pancreatic tumors (MESH:D010188), AP (MESH:D010195), viral infection (MESH:D014777), vascular obstruction (MESH:D057772), ischemia (MESH:D007511), alcohol abuse (MESH:D000437), epigastric pain (MESH:D010146), weight loss (MESH:D015431), infection (MESH:D007239), NENs (MESH:D009369), Liver metastasis (MESH:D009362), organomegaly (MESH:D016878), Pancreatic neuroendocrine tumors (MESH:D018358), jaundice (MESH:D007565), gallstone pancreatitis (MESH:D042882), exocrine pancreatic cancer (MESH:D010190), vomiting (MESH:D014839), tenderness (MESH:D063806), trauma (MESH:D014947), epithelial neoplasms (MESH:D009375), pNET (MESH:D018242)
- **Chemicals:** 5-fluorouracil (MESH:D005472), etoposide (MESH:D005047), cisplatin (MESH:D002945), alcohol (MESH:D000438), streptozocin (MESH:D013311)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12079377/full.md

## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12079377/full.md

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Source: https://tomesphere.com/paper/PMC12079377