# Pleomorphic adenoma of the lip: a case report and literature review

**Authors:** Rawa M Ali, Rebaz M Ali, Aras J Qaradakhy, Dilan S Hiwa, Ari M Abdullah, Diyar A Omar, Shko H Hassan, Abdullah A Qadir, Abdulwahid M Salih, Fahmi H Kakamad

PMC · DOI: 10.1093/jscr/rjaf311 · Journal of Surgical Case Reports · 2025-05-15

## TL;DR

This paper reports a rare case of a pleomorphic adenoma in the upper lip of a young man and emphasizes the importance of complete surgical removal to prevent recurrence.

## Contribution

The novelty lies in presenting a rare case of upper lip pleomorphic adenoma in a young adult and reinforcing diagnostic and treatment considerations.

## Key findings

- A 29-year-old male presented with a painless, slow-growing upper lip swelling confirmed as pleomorphic adenoma.
- Complete surgical excision with clear margins prevented recurrence at the 7-month follow-up.
- Pleomorphic adenoma should be considered in the differential diagnosis of upper lip swellings.

## Abstract

Pleomorphic adenoma (PA) most commonly affects the major salivary glands but can also involve the minor salivary glands, particularly those of the hard and soft palate. However, the current study aims to present a case of upper lip PA. A 29-year-old male presented with a painless, firm, slow-growing swelling (1.5 × 1.5 cm) on the left upper lip. Ultrasonography showed a solid, hypoechoic nodule with irregular margins and mild peripheral vascularity. The encapsulated tumor was excised, and histopathology confirmed PA. At the 7-month follow-up, no evidence of recurrence was observed. Though typically seen in adults aged 40–70, PA can affect younger patients. Complete excision with clear margins is essential due to the risk of recurrence or malignant transformation. PA should be considered in the differential diagnosis of upper lip swellings.

## Linked entities

- **Diseases:** pleomorphic adenoma (MONDO:0008401)

## Full-text entities

- **Genes:** PLAG1 (PLAG1 zinc finger) [NCBI Gene 5324] {aka PSA, SGPA, SRS4, ZNF912}, IGF2 (insulin like growth factor 2) [NCBI Gene 3481] {aka C11orf43, GRDF, IGF-II, PP9974, SRS3}, HMGA2 (high mobility group AT-hook 2) [NCBI Gene 8091] {aka BABL, HMGI-C, HMGIC, LIPO, SRS5, STQTL9}
- **Diseases:** chromosomal abnormalities (MESH:D002869), ischemic insult (MESH:D002545), Salivary gland tumors (MESH:D012468), swelling (MESH:D004487), skin tags (MESH:C566904), PA (MESH:D008949), spasticity (MESH:D009128), weakness (MESH:D018908), benign neoplasm (MESH:D009369), head and neck tumors (MESH:D006258), anterior upper lip swelling (MESH:D008047), capsular rupture (MESH:D057851), intellectual disability (MESH:D008607), skin lesions (MESH:D012871), PAs (MESH:C535377), necrosis (MESH:D009336)
- **Chemicals:** Hematoxylin (MESH:D006416), eosin (MESH:D004801)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12078932/full.md

## References

14 references — full list in the complete paper: https://tomesphere.com/paper/PMC12078932/full.md

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Source: https://tomesphere.com/paper/PMC12078932