# Clinical Management of Peri-Aortitis Following Endovascular Aortic Repair for Abdominal Aortic Aneurysm

**Authors:** Yuriko Takeuchi, Noriyasu Morikage, Ryunosuke Sakamoto, Takahiro Mizoguchi, Makoto Samura, Takasuke Harada, Hiroshi Kurazumi, Ryo Suzuki, Kotaro Suehiro, Kimikazu Hamano

PMC · DOI: 10.3400/avd.oa.24-00143 · Annals of Vascular Diseases · 2025-05-13

## TL;DR

This study explores the clinical features and outcomes of peri-aortitis after aortic repair surgery, emphasizing the need for careful diagnosis and treatment.

## Contribution

The paper provides new clinical insights into the rare condition of peri-aortitis following EVAR, including its management and prognosis.

## Key findings

- Peri-aortitis occurred in 0.89% of EVAR cases, with most patients being male and having autoimmune or allergic histories.
- Symptoms included fever and pain, with some cases resolving spontaneously and others requiring steroid therapy.
- Aneurysm shrinkage was common, but no correlation was found between aneurysm growth and peri-aortitis development.

## Abstract

Objectives: Peri-aortitis following endovascular aneurysm repair (EVAR) is a rare phenomenon with unclear pathogenesis. In this study, we investigated its clinical features and sac prognosis.

Methods: A retrospective analysis was conducted on 1369 EVAR. Peri-aortitis was defined using post-EVAR computed tomography. Clinical and imaging data were assessed.

Results: Peri-aortitis following EVAR was identified in 12 patients (0.89%) with a mean age of 74 ± 8.9 years; 83.3% were male, and 41.7% had allergic or autoimmune histories. There were eight symptomatic cases (66.7%), including seven with fever, three with back or abdominal pain, and one with hydronephrosis. Precautionary antibiotic treatment was administered in five febrile cases. Although persistent and recurrent inflammation was observed in two cases (16.7%) each, inflammation resolved spontaneously in seven patients (58.3%). One (8.3%) needed steroid therapy for severe back pain. Aneurysm shrinkage was observed in seven cases (58.3%), while enlargement was noted in one case (8.3%) with type II endoleak. No correlation was found between aneurysm growth and peri-aortitis development.

Conclusions: Peri-aortitis following EVAR may present significant challenges, including differentiation from infection, management of symptomatic cases requiring medical therapy, and addressing recurrences. Accurate diagnosis, individualized treatment, and meticulous follow-up are essential for favorable outcomes.

## Linked entities

- **Diseases:** abdominal aortic aneurysm (MONDO:0005350)

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}
- **Diseases:** retroperitoneal fibrosis (MESH:D012185), inflammatory aortic aneurysms (MESH:D001014), IgG4 (MESH:D000077733), fever (MESH:D005334), allergic (MESH:D004342), PIS (MESH:D000094025), abdominal or back pain (MESH:D015746), allergic or autoimmune diseases (MESH:D001327), back pain (MESH:D001416), infection (MESH:D007239), intimal injury (MESH:C563733), hydronephrosis (MESH:D006869), xanthogranuloma (MESH:D014972), Peri-Aortitis (MESH:D001025), Abdominal Aortic Aneurysm (MESH:D017544), type II endoleak (MESH:D057867), Peri (MESH:D057873), Inflammation (MESH:D007249), Aneurysm (MESH:D000783), thrombus (MESH:D013927), febrile (MESH:D000071072), Graft (MESH:D055589), rupture (MESH:D012421), edema (MESH:D004487), pseudoaneurysm (MESH:D017541)
- **Chemicals:** Steroids (MESH:D013256), tamoxifen (MESH:D013629), NA (MESH:D012964), Fluorodeoxyglucose (MESH:D019788)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12078785/full.md

## References

21 references — full list in the complete paper: https://tomesphere.com/paper/PMC12078785/full.md

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Source: https://tomesphere.com/paper/PMC12078785