# The role of immune dysregulation in the pathogenesis of type 1 diabetes: a paradigm shift in prevention strategies

**Authors:** Rajiv G. Gopalsamy, Hariharan Govindasamy, Jessiane B. de Souza, Deise M. R. R. Silva, Pedro H. M. Moura, Ronaldy S. Santos, Marina dos S. Barreto, Adriana G. Guimarães, Lucas A. da M. Santana, Lysandro P. Borges, Eloia E. D. Silva

PMC · DOI: 10.17179/excli2025-8233 · EXCLI Journal · 2025-04-03

## Full-text entities

- **Genes:** IFNG (interferon gamma) [NCBI Gene 3458] {aka IFG, IFI, IMD69}, GAD2 (glutamate decarboxylase 2) [NCBI Gene 2572] {aka GAD65}, INS (insulin) [NCBI Gene 3630] {aka IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10}, PTPRN (protein tyrosine phosphatase receptor type N) [NCBI Gene 5798] {aka IA-2, IA-2/PTP, IA2, ICA512, R-PTP-N}, IL1B (interleukin 1 beta) [NCBI Gene 3553] {aka IL-1, IL1-BETA, IL1F2, IL1beta}, SLC30A8 (solute carrier family 30 member 8) [NCBI Gene 169026] {aka ZNT8, ZnT-8}
- **Diseases:** diabetes (MESH:D003920), immune dysregulation (OMIM:614878), inflammation (MESH:D007249), infections (MESH:D007239), DKA (MESH:D016883), immune dysfunction (MESH:D007154), AID (MESH:D001327), glucose intolerance (MESH:D018149), T1D (MESH:D003922), vitiligo (MESH:D014820), celiac disease (MESH:D002446), Hashimoto's thyroiditis (MESH:D050031), hyperglycemia (MESH:D006943), viral infections (MESH:D014777)
- **Chemicals:** teplizumab (MESH:C502540)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC12078776/full.md

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Source: https://tomesphere.com/paper/PMC12078776