This paper is marked retracted in the scholarly record (OpenAlex). Interpret its findings with caution.
RETRACTION: The Increased PTK7 Expression Is a Malignant Factor in Cervical Cancer
Disease Markers

Abstract
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsKruppel-like factors research · Cancer-related molecular mechanisms research · Cancer-related Molecular Pathways
RETRACTION: J.-J. Sun, H.-L. Li, S.-J. Guo, H. Ma, S.-J. Liu, D. Liu, and F.-X. Xue. “The Increased PTK7 Expression Is a Malignant Factor in Cervical Cancer,” Disease Markers, no. 2019 (2019): 1–10. https://doi.org/10.1155/2019/5380197.
The above article, published online on 3 March 2019 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by John Wiley & Sons Ltd.
The retraction has been agreed following an investigation of the concerns raised by Hoya camphorifolia on PubPeer [1], which identified multiple instances of inappropriately overlapping figures.
Specifically:
- -Figure 2b: The Western Blot bands corresponding to PTK7 and β-actin expression in the MG-63 cells have been duplicated in 2 other papers with some rearrangements (Figure 2b in [2] and Figure 2b in [3]) and labelled as other proteins and cell types.
- -Figure 3a: The image of the cell cultures is identical to the 5637 cells shown in Figure 3a of [4], where it was labelled as a different cell type expressing a different target protein.
- -Figure 3d: The Western blot bands for PCNA and β-actin on the right side of the figure are identical to the bands corresponding to Ki67 and β-actin in the right panel of [5].
- -Figure 4d (left) /5d: The Western Blot images appear to be duplicated, while denoting different proteins.
- -Figure 5a: The second and third tumors in the top row as well as the first, second, and fourth tumors in the bottom row appear identical to the second and third tumors in the top row and the first 3 tumors in the bottom row in Figure 4a of [6]. The tumors also appear in Figure 5a of [7].
- -Figure 5b: The images of the two tumors above the graph have been duplicated in Figure 5b of [7] and Figure 4b of [8], while denoting different tissues.
- -Figure 5c: The immunohistochemistry panel in the top right of the figure has been duplicated in Figure 4c (right) of [8], and Figure 6d (right) of [9]. The image is labelled as a different tissue type in each manuscript.
As a result of the investigation, the data and conclusions of this article are considered unreliable.
Hong-Lin Li disagrees with this retraction. The other authors were informed of this decision but did not provide a response.
The reference list from the paper itself. Each links out to its DOI / PubMed record.
- 1Hoya camphorifolia The Increased PTK 7 Expression Is a Malignant Factor in Cervical Cancer Pub Peer April 2023, https://pubpeer.com/publications/CCB 162A 11B 29CCE 91F 815B 29EBB 88F
- 2Cui L. Zhang J.-Y. Ren Z.-P. Zhao H.-J. Li G.-S. APLNR Promotes the Progression of Osteosarcoma by Stimulating Cell Proliferation and Invasion Anti-Cancer Drugs 201930994094710.1097/CAD.00000000000007852-s 2.0-8507215168130920988 · doi ↗ · pubmed ↗
- 3Lin P. Liang L.-Y. Dong Y.-Z. Ren Z.-P. Zhao H.-J. Li G.-S. Identification of Abnormal Spindle Microtubule Assembly as a Promising Therapeutic Target for Osteosarcoma Orthopaedic Surgery 20201261963197010.1111/os.1279633078894 PMC 7767677 · doi ↗ · pubmed ↗
- 4Li K. Li S. Tang S. et al. KIF 22 Promotes Bladder Cancer Progression by Activating the Expression of CDCA 3 International Journal of Molecular Medicine 202148610.3892/ijmm.2021.50441 PMC 852295934633053 · doi ↗ · pubmed ↗
- 5Tian D.-W. Wu Z.-L. Jiang L.-M. Gao J. Wu C.-L. Hu H.-L. KIF 5A Promotes Bladder Cancer Proliferation In Vitro and In Vivo Disease Markers 20192019910.1155/2019/48249022-s 2.0-85069768376 PMC 663644031354888 · doi ↗ · pubmed ↗
- 6Li Z.-Y. Wang Z.-X. Li C.-C. Kinesin Family Member 20B Regulates Tongue Cancer Progression by Promoting Cell Proliferation Molecular Medicine Reports 20191932202221010.3892/mmr.2019.98512-s 2.0-8506114467630664160 PMC 6390006 · doi ↗ · pubmed ↗
- 7Xiaofei L. V. Yu X.-I. Xu J. Wang M. Peng C. KIF 18A Is a Potential Prognostic Factor and Promotes Tumor Progression in Oral Tongue Squamous Cell Carcinoma Biocell 20224651189119610.32604/biocell.2022.018249 · doi ↗
- 8Chen F.-T. Zhong F.-K. Kinesin Family Member 18A (KIF 18A) Contributes to the Proliferation, Migration, and Invasion of Lung Adenocarcinoma Cells In Vitro and In Vivo Disease Markers 201920191910.1155/2019/6383685 PMC 685499131772692 · doi ↗ · pubmed ↗
