# Idiopathic Spontaneous Pneumomediastinum in an Active Patient With Crohn’s Disease

**Authors:** Jake A Cresta, Azfar S Syed, Jared S Magee, John G McCarthy

PMC · DOI: 10.7759/cureus.82256 · Cureus · 2025-04-14

## TL;DR

A 30-year-old woman with Crohn’s disease developed a rare lung condition without clear cause, likely linked to her disease flare and steroid use.

## Contribution

Highlights idiopathic pneumomediastinum as a possible extraintestinal complication of Crohn’s disease during steroid therapy.

## Key findings

- Pneumomediastinum occurred without evidence of perforation in a Crohn’s patient during a flare.
- Conservative treatment resolved the condition, suggesting non-surgical management is viable in select cases.

## Abstract

Spontaneous pneumomediastinum (SPM) is a rare complication of inflammatory bowel disease (IBD), often associated with colonic perforations or procedural interventions. This report details a case of a 30-year-old female with ileocolonic Crohn’s disease (CD) presenting with idiopathic SPM during an acute CD flare while on prolonged corticosteroid therapy. Imaging confirmed pneumomediastinum without evidence of esophageal or colonic perforation. Conservative management with supportive care and prophylactic antimicrobials led to clinical resolution. This case underscores the importance of recognizing SPM as a potential extraintestinal complication of CD, particularly in the context of prolonged steroid use.

## Linked entities

- **Diseases:** Crohn’s disease (MONDO:0005011), inflammatory bowel disease (MONDO:0005265)

## Full-text entities

- **Genes:** TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}, CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}, IL23A (interleukin 23 subunit alpha) [NCBI Gene 51561] {aka IL-23, IL-23A, IL23P19, P19, SGRF}, IL12B (interleukin 12B) [NCBI Gene 3593] {aka CLMF, CLMF2, IL-12B, IMD28, IMD29, NKSF}
- **Diseases:** mood disturbances (MESH:D019964), emphysema (MESH:D004646), dysphagia (MESH:D003680), hyperemia (MESH:D006940), fistulas (MESH:D005402), abdominal tenderness (MESH:D000007), interstitial lung disease (MESH:D017563), opportunistic infections (MESH:D009894), liver disease (MESH:D008107), toxic megacolon (MESH:D008532), thrombocytosis (MESH:D013922), colonic or esophageal perforation (MESH:D004939), CD (MESH:D003424), leukocytosis (MESH:D007964), rupture (MESH:D012421), dyspnea (MESH:D004417), mediastinitis (MESH:D008480), ulcers (MESH:D014456), bone-mineral disease (MESH:D012080), anal stenosis (MESH:D001005), Idiopathic Spontaneous Pneumomediastinum (MESH:D008478), lung disease (MESH:D008171), alveolar (MESH:D002282), chest trauma (MESH:D013898), ulcerative colitis (MESH:D003093), IBD (MESH:D015212), abdominal pain (MESH:D015746), autoimmune (MESH:D001327), perforation (MESH:D057112), bronchiectasis (MESH:D001987), diarrhea (MESH:D003967), infections (MESH:D007239), gastrointestinal infectious disease (MESH:D003141), metabolic and endocrinologic dysfunction (MESH:D008659), pyrosis (MESH:D006356), inflammation (MESH:D007249), colonic perforations (MESH:D015179)
- **Chemicals:** Gastrografin (MESH:D003974), fluconazole (MESH:D015725), prednisone (MESH:D011241), adalimumab (MESH:D000068879), amoxicillin-clavulanic acid (MESH:D019980), vedolizumab (MESH:C543529), steroid (MESH:D013256), ustekinumab (MESH:D000069549), infliximab (MESH:D000069285)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12077858/full.md

## References

18 references — full list in the complete paper: https://tomesphere.com/paper/PMC12077858/full.md

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Source: https://tomesphere.com/paper/PMC12077858