# Histological effect of fluoride varnishes on teeth with caries in the white spot phase: An in vitro study

## TL;DR

This study compared two fluoride varnishes to see which is better at remineralizing early tooth decay in lab-grown teeth.

## Contribution

The study provides new empirical evidence on the effectiveness of MI Varnish TM over Clinpro TM White Varnish for dental remineralization.

## Key findings

- MI Varnish TM showed a significantly larger remineralization area compared to Clinpro TM White Varnish.
- The study found statistically significant differences in the remineralization effects of the two varnishes.
- MI Varnish TM was more effective in treating early caries lesions in young permanent teeth.

## Abstract

The aim of this study was to compare the histological remineralization effects of two fluoride varnishes on artificially produced caries lesions in young permanent teeth.

Twenty longitudinal sections of premolars with artificially produced white spot lesions and evaluated with a polarised light microscope. The sample consisted of 20 tooth fragments, which were divided and assigned to two groups: The first group with application of Clinpro TM White Varnish (20 tooth sections) and the second, with MI Varnish TM (20 tooth sections) subjected for 6 days to conditions similar to the oral cavity. The sections were then re-evaluated by calculating the lesion depth and remineralization area (Image J software). Student’ s t-test was used to analyse the data.

MI Varnish TM fluoride varnish achieved a greater remineralization area than Clinpro TM White Varnish (838042.6±140359.3 μm2 and 678313.8±137265.7μm2, respectively), with a statistically significant difference (p<0.05).

MI Varnish TM had a better effect than Clinpro TM White Varnish in remineralizing lesions, in vitro, in the enamel of young permanent teeth with caries in the white-stained phase.

Key words:Fluorides varnishes, histological effect, dental remineralization, polarised light microscope.