# Exploring Tau-C, Tau-A, and C1M as biomarkers for Parkinson’s disease

**Authors:** Meryem Benmarce, Kim Henriksen, Morten Karsdal, Signe Holm Nielsen

PMC · DOI: 10.3389/fneur.2025.1566228 · Frontiers in Neurology · 2025-04-30

## TL;DR

This study explores blood-based biomarkers Tau-C, Tau-A, and C1M for diagnosing Parkinson’s disease, showing strong potential for distinguishing PD patients from healthy individuals.

## Contribution

The study identifies Tau-C, Tau-A, and C1M as novel blood-based biomarkers for Parkinson’s disease diagnosis.

## Key findings

- Tau-C, Tau-A, and C1M effectively differentiate PD patients from healthy donors (p < 0.001).
- Tau-C showed the highest diagnostic accuracy with an AUROC of 0.97.

## Abstract

Tau has shown to be associated with neurodegenerative diseases. In this exploratory study, we investigated the utility of blood-based biomarkers measuring Tau-C, Tau-A, and C1M in Parkinson’s disease (PD) to explore their potential as diagnostic biomarkers in two independent cohorts (TAU-C and TAU-A). We found them to discriminate between healthy donors and PD individuals (all p < 0.001), with Tau-C showing the best diagnostic discrepancy (AUROC = 0.97). Therefore, Tau-C, Tau-A, and C1M may be biomarkers for PD diagnosis.

## Linked entities

- **Proteins:** tauC (taurine ABC transporter permease), tauA (taurine ABC transporter periplasmic binding protein)
- **Diseases:** Parkinson’s disease (MONDO:0005180)

## Full-text entities

- **Genes:** ADAM10 (ADAM metallopeptidase domain 10) [NCBI Gene 102] {aka AD10, AD18, CD156c, CDw156, HsT18717, MADM}, COMT (catechol-O-methyltransferase) [NCBI Gene 1312] {aka HEL-S-98n}, CASP3 (caspase 3) [NCBI Gene 836] {aka CPP32, CPP32B, SCA-1}, SNCA (synuclein alpha) [NCBI Gene 6622] {aka NACP, PARK1, PARK4, PD1}, MAPT (microtubule associated protein tau) [NCBI Gene 4137] {aka DDPAC, FTD1, FTDP-17, MAPTL, MSTD, MTBT1}
- **Diseases:** postural instability (MESH:D054972), neurodegeneration (MESH:D019636), dopamine deficiency (MESH:C567730), AD (MESH:D000544), dopaminergic deficiency (MESH:D009422), depression (MESH:D003866), neuroinflammation (MESH:D000090862), inflammation (MESH:D007249), constipation (MESH:D003248), resting tremor (MESH:D014202), sleep disorders (MESH:D012893), PD (MESH:D010300), dopaminergic hypofunction (MESH:D000309), neuronal degeneration (MESH:D009410), dementia (MESH:D003704), loss of smell (MESH:D000086582), Lewy body (MESH:D020961), bradykinesia (MESH:D018476)
- **Chemicals:** levodopa (MESH:D007980), C1M (-), dopamine (MESH:D004298)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Mutations:** P301L

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12077818/full.md

## References

18 references — full list in the complete paper: https://tomesphere.com/paper/PMC12077818/full.md

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Source: https://tomesphere.com/paper/PMC12077818