# Rapid chronic kidney disease progression in younger, First Nations patients in the Northern Territory

**Authors:** Winnie Chen, Oyelola Adegboye, Gillian Gorham, Asanga Abeyaratne, Sandawana William Majoni, Sean Taylor, Samuel Heard, Harshana Munasinghe, Matthew J. L. Hare, Alan Cass

PMC · DOI: 10.1111/imj.70062 · Internal Medicine Journal · 2025-04-22

## TL;DR

Younger First Nations patients in Australia's Northern Territory experience faster chronic kidney disease progression, highlighting the need for early interventions.

## Contribution

Identifies younger First Nations patients as a high-risk group for rapid CKD progression in a remote Australian setting.

## Key findings

- Younger patients under 50 had higher risk of progressing to kidney replacement therapy or death.
- CKD progression is more rapid in younger First Nations individuals in the Northern Territory.
- Early intervention is critical for younger patients to prevent severe outcomes.

## Abstract

This 6‐year retrospective cohort study investigated the progression of chronic kidney disease (CKD) among Australian First Nations patients in remote Northern Territory. We found that younger patients (age less than 50 years) were at a higher risk of progression to kidney replacement therapy or death compared to older adults. The results indicate a need to target early CKD intervention efforts to younger patients at risk of rapid progression.

## Linked entities

- **Diseases:** chronic kidney disease (MONDO:0005300)

## Full-text entities

- **Diseases:** death (MESH:D003643), CKD (MESH:D051436)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12077581/full.md

## References

16 references — full list in the complete paper: https://tomesphere.com/paper/PMC12077581/full.md

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Source: https://tomesphere.com/paper/PMC12077581