# Mucinous adenocarcinoma in the axilla of undetermined origin

**Authors:** Chloe Spillane, Roisin Daly, Mar Cotter, Kristali Ylli, Wala Eljack, Ciaran Sheehan, Corina Girleanu, Michael Bennett, Aongus Twomey

PMC · DOI: 10.1093/jscr/rjaf258 · Journal of Surgical Case Reports · 2025-05-14

## TL;DR

A 75-year-old man had mucinous adenocarcinoma in his axilla with no clear origin, leading to close monitoring instead of further treatment.

## Contribution

This case report presents an atypical axillary mucinous adenocarcinoma of undetermined origin, adding to the limited literature on primary cutaneous mucinous adenocarcinoma.

## Key findings

- The patient had mucinous adenocarcinoma in the axilla with no identifiable primary source.
- Immunohistochemistry suggested possible breast or primary cutaneous origin.
- The patient remains asymptomatic with no evidence of metastasis in axillary nodes.

## Abstract

Mucinous adenocarcinoma (MAC), accounts for ⁓1% of all cancer diagnoses. We present a case of a 75-year-old male who, after presenting for an elective inguinal hernia repair, disclosed concerns for a new lesion in his right axilla which was removed at the same time. Investigations revealed a MAC of unclear origin, with immunohistochemistry suggesting either a breast or primary cutaneous mucinous adenocarcinoma (PCMC). The patient was asymptomatic with an otherwise normal examination. Extensive investigations failed to identify any primary source. Axillary node clearance was performed, resulting in 0/9 positive nodes. After multi-disciplinary team discussion, this patient (who remains asymptomatic) will be kept under close clinical surveillance, with yearly computerized tomography scans. To our knowledge, minimal presentations have been reported in the literature. Thus, our case report is a unique addition of an atypical presentation of PCMC in the axilla.

## Linked entities

- **Diseases:** mucinous adenocarcinoma (MONDO:0004957)

## Full-text entities

- **Genes:** CEACAM3 (CEA cell adhesion molecule 3) [NCBI Gene 1084] {aka CD66D, CEA, CGM1, CGM1a, W264, W282}, KRT20 (keratin 20) [NCBI Gene 54474] {aka CD20, CK-20, CK20, K20, KRT21}, NPEPPS (aminopeptidase puromycin sensitive) [NCBI Gene 9520] {aka AAP-S, MP100, PSA}, PGR (progesterone receptor) [NCBI Gene 5241] {aka NR3C3, PR}, ERBB2 (erb-b2 receptor tyrosine kinase 2) [NCBI Gene 2064] {aka CD340, HER-2, HER-2/neu, HER2, MLN 19, MLN-19}, EREG (epiregulin) [NCBI Gene 2069] {aka EPR, ER, Ep}, GATA3 (GATA binding protein 3) [NCBI Gene 2625] {aka HDR, HDRS}, SOX10 (SRY-box transcription factor 10) [NCBI Gene 6663] {aka DOM, PCWH, SOX-10, WS2E, WS4, WS4C}, CDKN2A (cyclin dependent kinase inhibitor 2A) [NCBI Gene 1029] {aka ARF, CAI2, CDK4I, CDKN2, CMM2, INK4}, TTF1 (transcription termination factor 1) [NCBI Gene 7270] {aka TTF-1, TTF-I}, Mucin [NCBI Gene 100508689], IL9 (interleukin 9) [NCBI Gene 3578] {aka HP40, IL-9, P40}, TP63 (tumor protein p63) [NCBI Gene 8626] {aka AIS, B(p51A), B(p51B), EEC3, KET, LMS}, MUC1 (mucin 1, cell surface associated) [NCBI Gene 4582] {aka ADMCKD, ADMCKD1, ADTKD2, CA 15-3, CD227, Ca15-3}, KRT7 (keratin 7) [NCBI Gene 3855] {aka CK7, K2C7, K7, SCL}, CDX2 (caudal type homeobox 2) [NCBI Gene 1045] {aka CDX-3, CDX2/AS, CDX3}
- **Diseases:** cutaneous lesions (MESH:D009059), neuroma (MESH:D009463), epidermal cyst (MESH:D004814), sebaceous carcinoma (MESH:D012626), basal cell carcinoma (MESH:D002280), squamous cell carcinoma (MESH:D002294), breast MAC (MESH:D061325), inguinal hernia (MESH:D006552), pilomatrixoma (MESH:D018296), breast or primary cutaneous mucinous adenocarcinoma (MESH:D001943), MAC (MESH:D002288), lymphadenopathy (MESH:D008206), metastases (MESH:D009362), hernia (MESH:D006547), malignancy (MESH:D009369)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12077391/full.md

## References

13 references — full list in the complete paper: https://tomesphere.com/paper/PMC12077391/full.md

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Source: https://tomesphere.com/paper/PMC12077391