# An Atypical Case of Chronic Fungal Rhinosinusitis: Temporary Symptom Relief Resulted in a Delay of Diagnosis and Brain Abscess

**Authors:** Mio Yamamoto, Takeshi Takahashi, Ryota Kai, Tetsuhisa Hatase, Arata Horii

PMC · DOI: 10.7759/cureus.82226 · Cureus · 2025-04-14

## TL;DR

A diabetic man's fungal sinus infection was delayed due to temporary symptom relief, leading to severe complications like brain abscess.

## Contribution

Highlights how transient symptom remission can mask chronic fungal rhinosinusitis progression, stressing the need for early diagnosis.

## Key findings

- Mild and remitting symptoms delayed diagnosis of invasive fungal rhinosinusitis.
- Spontaneous resolution of symptoms led to 11 months without treatment, resulting in brain abscess.
- Emergency surgery and antifungal therapy could not prevent vision loss.

## Abstract

A 67-year-old diabetic man with chronic invasive fungal rhinosinusitis (IFRS) experienced mild, remitting visual symptoms, delaying diagnosis. Despite early MRI evidence of orbital apex inflammation, spontaneous symptom resolution led to discontinuation of hospital visit. Eleven months later, he developed orbital apex syndrome and intracranial complications. Emergency surgery and antifungal therapy were initiated, but vision loss persisted. This case underscores the risk of transient symptom remission masking IFRS progression, emphasizing the importance of early intervention.

## Linked entities

- **Diseases:** diabetes (MONDO:0005015)

## Full-text entities

- **Diseases:** controlled diabetes mellitus (MESH:D003920), OAS (MESH:D009916), vision loss (MESH:D014786), Inflammation (MESH:D007249), death (MESH:D003643), retro-orbital pain (MESH:D010146), optic neuropathy (MESH:D009901), myosis (MESH:D036821), bone (MESH:D001847), afferent pupillary defect (MESH:D011681), brain abscess (MESH:D001922), well (MESH:C536693), IFRS (MESH:D000092562), diabetic retinopathy (MESH:D003930), blind (MESH:D001766), abscess (MESH:D000038), intracranial complications (MESH:D008107), type II diabetes mellitus (MESH:D003924), eyelid ptosis (MESH:D001763), headache (MESH:D006261), cataract (MESH:D002386), optic nerve deviation (MESH:D000080344), facial pain (MESH:D005157)
- **Chemicals:** glucose (MESH:D005947), vancomycin (MESH:D014640), voriconazole (MESH:D065819), PG (-), meropenem (MESH:D000077731), blood sugar (MESH:D001786)
- **Species:** Aspergillus (genus) [taxon 5052], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

7 references — full list in the complete paper: https://tomesphere.com/paper/PMC12076527/full.md

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Source: https://tomesphere.com/paper/PMC12076527