# Synthesis of Flexible Random Copolymers of Poly(butylene trans-1,4-ciclohexanedicarboxylate) Containing Pripol Moiety as Potential Candidates for Vascular Applications: Solid-State Characterization and Preliminary In Vitro Biocompatibility and Hemocompatibility

## TL;DR

Researchers developed flexible copolymers for vascular applications that are biocompatible and do not cause blood clotting.

## Contribution

A new family of copolymers with Pripol moieties was synthesized, offering improved flexibility and biocompatibility for vascular use.

## Key findings

- The copolymers have reduced crystallinity and stiffness compared to PBCE.
- The materials showed no cytotoxicity and maintained blood compatibility.
- The design of the copolymers allows for regulation of solid-state and functional properties.

## Abstract

In order to envisage new solutions for complications
associated
with cardiovascular diseases, including the occlusion of small vessels,
a family of random copolymers of poly(butylene trans-1,4-ciclohexanedicarboxylate) (PBCE), containing Pripol moiety,
namely, poly(butylene trans-1,4-ciclohexaendicarboxylate/Pripol),
were successfully synthesized. The copolymers display reduced crystallinity
and stiffness compared with PBCE, exhibiting elastic modulus values
that are comparable to those of materials previously investigated
for similar applications. The stability of the materials under physiological
conditions was demonstrated over an extended time. Cytotoxicity was
confirmed by a direct contact assay with human umbilical vein endothelial
cells (HUVECs), and blood compatibility was established by the absence
of any change in the values of activated prothrombin time and activated
partial thromboplastin time, in addition to the low adhesion of blood
components. The results demonstrated that the ad hoc design is pivotal
in regulating solid state and functional properties, thereby facilitating
the development of innovative materials for vascular tissue engineering.