# Identification of deferasirox as a human xanthine oxidase inhibitor

**Authors:** Yunfei Qi, Xinheng He, Xiaoshan Wu, Tingting Zhou, Ningning Liang, Jiazheng Jiao, Yanhao Chen, Yue Yuan, Yuwei Zhang, Yucheng Wang, Yan Liu, Qiurong Ding

PMC · DOI: 10.1093/lifemedi/lnaf014 · Life Medicine · 2025-03-31

## Full-text entities

- **Genes:** XDH (xanthine dehydrogenase) [NCBI Gene 7498] {aka XAN1, XDH/XO, XO, XOR}, UOX (urate oxidase (pseudogene)) [NCBI Gene 391051] {aka UOXP, URICASE}, IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}, HAVCR1 (hepatitis A virus cellular receptor 1) [NCBI Gene 26762] {aka CD365, HAVCR, HAVCR-1, KIM-1, KIM1, TIM}, NLRP3 (NLR family pyrin domain containing 3) [NCBI Gene 114548] {aka AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1}, TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}
- **Diseases:** metabolic syndrome (MESH:D024821), Hyperuricemia (MESH:D033461), nephropathy (MESH:D007674), inflammation (MESH:D007249), iron overload (MESH:D019190), gout (MESH:D006073), mHUA (MESH:D004482), cardiovascular diseases (MESH:D002318), toxicity (MESH:D064420), XO (MESH:C562584), type 2 diabetes (MESH:D003924)
- **Chemicals:** febuxostat (MESH:D000069465), Deferasirox (MESH:D000077588), creatinine (MESH:D003404), Fe-S (MESH:D007501), allantoin (MESH:D000481), urea nitrogen (MESH:C530477), DMSO (MESH:D004121), FAD (MESH:D005182), guanosine (MESH:D006151), UA (MESH:D014527), xanthine (MESH:D019820), topiroxostat (MESH:C504882), metal (MESH:D008670), inosine (MESH:D007288), purine (MESH:C030985), hypoxanthine (MESH:D019271), Allopurinol (MESH:D000493), CMC-Na (-), molybdenum (MESH:D008982)
- **Species:** Halosbaena sp. PH (species) [taxon 1904764], Mus musculus (house mouse, species) [taxon 10090], Homo sapiens (human, species) [taxon 9606]
- **Mutations:** C43A, Cys43 to alanine

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## Figures

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## References

9 references — full list in the complete paper: https://tomesphere.com/paper/PMC12075764/full.md

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Source: https://tomesphere.com/paper/PMC12075764