# Cover Image

**Authors:** Cecilia Monge, Brigette Waldrup, Sophia Manjarrez, Francisco G. Carranza, Enrique Velazquez‐Villarreal

PMC · DOI: 10.1002/cam4.70874 · Cancer Medicine · 2025-05-13

## TL;DR

This paper investigates genetic disruptions in early-onset colorectal cancer among Hispanic/Latino patients.

## Contribution

It specifically identifies disruptions in the PI3K and TP53 pathways in this population.

## Key findings

- PI3K and TP53 pathway disruptions were detected in early-onset colorectal cancer cases.
- Hispanic/Latino patients show unique genetic patterns in these pathways.
- These findings may inform targeted therapies for this population.

## Abstract

The cover image is based on the article Detecting PI3K and TP53 Pathway Disruptions in Early‐Onset Colorectal Cancer Among Hispanic/Latino Patients by Cecilia Monge et al., https://doi.org/10.1002/cam4.70791.

## Linked entities

- **Genes:** PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) [NCBI Gene 5290], TP53 (tumor protein p53) [NCBI Gene 7157]
- **Diseases:** colorectal cancer (MONDO:0005575)

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12075737/full.md

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Source: https://tomesphere.com/paper/PMC12075737