# Short-term memory retrieval enhances brain functional connectivity

**Authors:** Fanglei Duan, Xiangyu Yan, Jing Wang, Zhenhua Wu, Yixin Zhang, QiCheng Shu, Fangfang Liu, Fan Xu, Qin Han

PMC · DOI: 10.3389/fnbeh.2025.1578415 · Frontiers in Behavioral Neuroscience · 2025-04-30

## TL;DR

This study shows that short-term memory tasks increase brain connectivity and oxygenation, which may help improve memory skills and attention.

## Contribution

The study identifies specific brain regions and connectivity patterns linked to enhanced short-term memory performance.

## Key findings

- Short-term memory tasks increase activity in the prefrontal and motor cortices.
- Stronger memory performance correlates with higher heart rates and fewer negative emotions.
- Functional connectivity between brain regions improves during memory tasks.

## Abstract

Short-term memory poses a significant challenge, involving complex processes of image perception, memory formation, and execution. However, the mechanisms underlying the formation, storage, and execution of short-term memory remain poorly understood.

In this study, 41 healthy college students participated in a memory challenge test designed to investigate these processes. Functional near-infrared spectroscopy (fNIRS) was employed to measure dynamic changes in hemoglobin concentrations in specific cortical regions, while facial expressions and vital signs were recorded in real-time during the tests.

The results revealed heightened activity in the inferior prefrontal gyrus, visual association cortex, pre-motor cortex, and supplementary motor cortex. Functional connectivity between these regions was significantly enhanced during the tasks, and inter-group differences decreased over time. Participants with superior short-term memory exhibited lower levels of negative emotional expressions and higher heart rates compared to those with weaker memory performance. These findings suggest that cortical interconnectivity and adequate cerebral blood oxygenation play critical roles in enhancing short-term memory capacity. This has important implications for education, as it highlights strategies for cultivating attention, training memory skills, and improving memory integration abilities.

## Full-text entities

- **Genes:** FANCE (FA complementation group E) [NCBI Gene 2178] {aka FACE, FAE}
- **Diseases:** hypoxia (MESH:D000860), fatigue (MESH:D005221), neurological or psychiatric disorders (MESH:D001523), cognitive impairments (MESH:D003072), memory failure (MESH:D051437), Neutral mood (MESH:D019964), Diastolic Blood Pressure (MESH:D006337), drug abuse (MESH:D019966), metabolic diseases (MESH:D008659), poisoning (MESH:D011041), depression (MESH:D003866), infections (MESH:D007239), neurological or systemic diseases (MESH:D009422), anxiety (MESH:D001007)
- **Chemicals:** Oxygen (MESH:D010100), caffeine (MESH:D002110), HBO (-), alcohol (MESH:D000438), glucose (MESH:D005947)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

11 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12075360/full.md

## References

39 references — full list in the complete paper: https://tomesphere.com/paper/PMC12075360/full.md

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Source: https://tomesphere.com/paper/PMC12075360