# Conservative therapy of epidural hematoma with atorvastatin combined with glucocorticoids: cases report and literature review

**Authors:** Chenrui Wu, Yu Tian, Ruichen Zhao, Runfang Chen, Chuanlin Xu, Jinsheng Huang, Rongcai Jiang

PMC · DOI: 10.3389/fsurg.2025.1587988 · Frontiers in Surgery · 2025-04-30

## TL;DR

A conservative treatment combining atorvastatin and dexamethasone successfully managed epidural hematomas in six patients without surgery.

## Contribution

The study introduces a novel conservative therapy combining atorvastatin and glucocorticoids for stable epidural hematomas.

## Key findings

- All six patients with stable epidural hematomas recovered fully without surgery.
- The combination of atorvastatin and dexamethasone may promote hematoma absorption.
- Literature supports conservative management for selected epidural hematoma cases.

## Abstract

Epidural hematomas (EDH), typically requiring surgery, may be managed conservatively in select patients. We investigated atorvastatin (10 mg/day) combined with dexamethasone (2.25 mg/day) as conservative therapy in six EDH patients (GCS ≥ 13, volume < 30 ml) post-trauma. All patients recovered fully without surgery, and literatures support conservative care for stable EDH. Our findings suggest this combination therapy may promote hematoma absorption. In conclusion, atorvastatin/dexamethasone shows promise as a non-surgical EDH option, warranting further investigation.

## Linked entities

- **Chemicals:** atorvastatin (PubChem CID 60823), dexamethasone (PubChem CID 5743)

## Full-text entities

- **Genes:** VEGFA (vascular endothelial growth factor A) [NCBI Gene 7422] {aka L-VEGF, MVCD1, VEGF, VPF}
- **Diseases:** impaired consciousness (MESH:D003244), inflammation (MESH:D007249), CSDH (MESH:D020200), skull fractures (MESH:D012887), hematoma (MESH:D006406), infection (MESH:D007239), neurological function loss (MESH:D003291), cerebral edema (MESH:D001929), neurological deterioration (MESH:D009422), cerebral hemorrhage (MESH:D002543), trauma (MESH:D014947), neurological deficits (MESH:D009461), loss of consciousness (MESH:D014474), hemorrhage (MESH:D006470), MVA (MESH:D000081084), ischemic stroke (MESH:D002544), Coma (MESH:D003128), Brain Trauma (MESH:D000070642), head injuries (MESH:D006259), EDH (MESH:D046748)
- **Chemicals:** cholesterol (MESH:D002784), lipid (MESH:D008055), Dexamethasone (MESH:D003907), Atorvastatin (MESH:D000069059)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

37 references — full list in the complete paper: https://tomesphere.com/paper/PMC12075206/full.md

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Source: https://tomesphere.com/paper/PMC12075206