# Adult Intussusception Secondary to Varicella-Zoster Virus Infection

**Authors:** Jennifer Madukaife, Micah Pippin, George Collins, Diahann Marshall

PMC · DOI: 10.7759/cureus.82204 · Cureus · 2025-04-13

## TL;DR

This paper reports a rare case of adult intussusception linked to a varicella-zoster virus infection, highlighting the need for further research on this unusual connection.

## Contribution

The paper presents a novel clinical case linking VZV infection to intussusception in an adult, a rare and underreported phenomenon.

## Key findings

- The case describes intussusception occurring in the context of a varicella-zoster virus infection in an adult.
- The paper emphasizes the rarity of this association and calls for further investigation into VZV's potential role in gastrointestinal pathology.
- Early diagnosis and targeted management are highlighted as crucial in such cases.

## Abstract

Varicella-zoster virus (VZV), also known as human herpesvirus 3, is a double-stranded linear DNA virus. It can manifest as chickenpox in childhood and, much less commonly, in adulthood, and the latent virus can reemerge as shingles. This case investigates an unusual presentation of intussusception, telescoping of the bowel, in the context of varicella infection. Reports on this phenomenon are very rare, and the effects of VZV on gastrointestinal pathology are primarily theoretical. This case underscores the importance of early diagnosis and targeted management and the need for further investigation into the association between VZV and intussusception.

## Linked entities

- **Diseases:** varicella (MONDO:0005700), shingles (MONDO:0005609), intussusception (MONDO:0007835)

## Full-text entities

- **Diseases:** diabetes mellitus type 2 (MESH:D003924), obese (MESH:D009765), biliary obstruction (MESH:D001658), wheezing (MESH:D012135), ischemia (MESH:D007511), Postherpetic neuralgia (MESH:D051474), neuropathic enteric nervous system dysfunction (MESH:D004751), liver disease (MESH:D008107), maculovesicular rash (MESH:D005076), neuropathic intestinal sequelae (MESH:D007410), myocarditis (MESH:D009205), fatty (MESH:D008067), herpes viral infection (MESH:D014777), Shingles (MESH:D006562), pancreatitis (MESH:D010195), peritonitis (MESH:D010538), roseola (MESH:D005077), hyperlipidemia (MESH:D006949), hypertrophy (MESH:D006984), dyslipidemia (MESH:D050171), adenovirus C infection (MESH:D000257), hepatitis (MESH:D056486), fatty infiltration (MESH:D017254), Varicella (MESH:D002644), edema (MESH:D004487), ganglionitis (MESH:D045888), gastrointestinal complication (MESH:D005767), ischemic (MESH:D002545), vesicular eruption (MESH:D012872), pruritus (MESH:D011537), glomerulonephritis (MESH:D005921), cerebellar ataxia (MESH:D002524), sepsis (MESH:D018805), measles (MESH:D008457), tenderness (MESH:D063806), VZV eruption (MESH:D000073618), arthritis (MESH:D001168), bilious vomiting (MESH:D014839), COVID-19 (MESH:D000086382), Intussusception (MESH:D007443), choledocholithiasis (MESH:D042883), HIV antibody (MESH:D015658), necrosis (MESH:D009336), thrombocytopenia (MESH:D013921), monocytosis (MESH:C538328), fever (MESH:D005334), numbness (MESH:D006987), skin eruption (MESH:D012871), diabetic (MESH:D003920), leukopenia (MESH:D007970), neurologic sequelae (MESH:D009422), Laboratory abnormalities (MESH:D007757), hypersensitivity (MESH:D004342), uveitis (MESH:D014605), mumps (MESH:D009107), pneumonia (MESH:D011014), purpura fulminans (MESH:D055665), discoordinated (MESH:C562757), perforation (MESH:D057112), abdominal pain (MESH:D015746)
- **Chemicals:** Shingrix (-), Lipitor (MESH:D000069059), CO2 (MESH:D002245), Flagyl (MESH:D008795), prednisone (MESH:D011241), oxygen (MESH:D010100), Acyclovir (MESH:D000212), vancomycin (MESH:D014640), diphenhydramine (MESH:D004155), bilirubin (MESH:D001663), metformin (MESH:D008687), Zosyn (MESH:D000077725), steroid (MESH:D013256), Coreg (MESH:D000077261), enalapril (MESH:D004656), alcohol (MESH:D000438)
- **Species:** Rotavirus (genus) [taxon 10912], Homo sapiens (human, species) [taxon 9606], Human immunodeficiency virus (species) [taxon 12721], Human alphaherpesvirus 3 (Varicella-zoster virus, no rank) [taxon 10335], human gammaherpesvirus 4 (Epstein Barr virus, no rank) [taxon 10376], Human betaherpesvirus 6 (species) [taxon 10368], Human immunodeficiency virus 1 (no rank) [taxon 11676], Nicotiana tabacum (American tobacco, species) [taxon 4097]

## Full text

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## Figures

7 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12075024/full.md

## References

23 references — full list in the complete paper: https://tomesphere.com/paper/PMC12075024/full.md

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Source: https://tomesphere.com/paper/PMC12075024