# Isolated third cranial nerve palsy as the presenting sign of tuberculum sellae meningioma: a case report

**Authors:** Azizah Alotaibi, Fay Althunayyan, Shuroq Alshehri, Hosam Al-Jehani

PMC · DOI: 10.3389/fopht.2025.1525183 · Frontiers in Ophthalmology · 2025-04-30

## TL;DR

A rare case of isolated third cranial nerve palsy caused by a meningioma was successfully treated with corticosteroids.

## Contribution

This is the first reported case of isolated third cranial nerve palsy associated with tuberculum sellae meningioma and rapid recovery with corticosteroids.

## Key findings

- Isolated third cranial nerve palsy was the presenting sign of a tuberculum sellae meningioma.
- Treatment with dexamethasone led to rapid and complete recovery of the nerve palsy.
- This case highlights the potential role of corticosteroids in managing isolated ocular motor nerve palsy.

## Abstract

Tuberculum sellae meningioma (TSM) is an uncommon tumor among all intracranial meningiomas. As these tumors grow, they compress the surrounding structures, including the optic nerves and the pituitary gland. Ocular motor nerve palsy (OMNP) can occur as an isolated mononeuropathy or as part of multiple cranial nerve palsies. The role of corticosteroids in the management of OMNP has not been fully studied in the literature. In this report, we present a case of a previously well middle-aged woman who presented with severe headache and isolated OMNP on examination. MRI of the brain showed a small TSM that extends into the right optic canal. In our case, we noted the expedient and complete recovery of isolated OMNP within a few days following treatment with dexamethasone. This case report is on an isolated OMNP associated with TSM, which has not been previously reported. In addition, it highlights the role of corticosteroids in achieving rapid recovery from OMNP.

## Linked entities

- **Chemicals:** dexamethasone (PubChem CID 5743)
- **Diseases:** tuberculum sellae meningioma (MONDO:0004339)

## Full-text entities

- **Diseases:** Acquired oculomotor nerve palsy (MESH:D015840), seizures (MESH:D012640), conjunctival congestion (MESH:D003229), optic nerve compression (MESH:D009408), hemianopsia (MESH:D006423), stenosis (MESH:D003251), VFDs (MESH:D005128), neuro-ophthalmological condition (MESH:C536203), acute nerve palsy (MESH:D040701), multi-neuropathy (MESH:D015161), aneurysm (MESH:D000783), ischemia (MESH:D007511), headache (MESH:D006261), limitation of adduction (MESH:C562949), diplopia (MESH:D004172), vomiting (MESH:D014839), OMNP (MESH:D003389), TSM (MESH:D004652), coronavirus disease 2019 (COVID-19) infection (MESH:D000086382), a decrease in visual acuity (MESH:D014786), trauma (MESH:D014947), meningioma (MESH:D008579), brain lesions (MESH:D001927), nausea (MESH:D009325), optic disc atrophy (MESH:D009896), ptosis (MESH:C564553), pain (MESH:D010146), intracranial tumors (MESH:D009369), mononeuropathy (MESH:D020422), microvascular injury (MESH:D017566)
- **Chemicals:** dexamethasone (MESH:D003907), prednisolone (MESH:D011239)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC12074959/full.md

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Source: https://tomesphere.com/paper/PMC12074959