# Case Report: Thoracic duct ligation for left-sided chylothorax after pneumonectomy with contralateral VATS procedure using indocyanine green fluorescence

**Authors:** Chiara Anna Schiena, Mario Pezzella, Eleonora Faccioli, Alessandro Rebusso, Giovanni Comacchio, Stefano Silvestrin, Michele Battistel, Edoardo Rosellini, Andrea Dell’Amore, Federico Rea, Samuele Nicotra

PMC · DOI: 10.3389/fsurg.2025.1558519 · Frontiers in Surgery · 2025-04-29

## TL;DR

A 62-year-old man with chylothorax after left pneumonectomy underwent successful thoracic duct ligation using indocyanine green fluorescence during VATS.

## Contribution

Demonstrates the use of ICG fluorescence to aid thoracic duct identification after left pneumonectomy.

## Key findings

- ICG fluorescence successfully identified the thoracic duct during VATS after left pneumonectomy.
- Conservative and embolization treatments failed, necessitating surgical intervention.
- A single-lumen endotracheal tube with a bronchial blocker enabled selective lung exclusion during surgery.

## Abstract

Chylothorax is a rare but potentially life-threatening condition characterized by the accumulation of lymphatic fluid in the pleural cavity. It is typically managed with conservative treatments such as fasting and/or thoracic duct embolization via lymphography. However, when these approaches fail, surgical intervention, most commonly thoracic duct ligation (TDL), is often necessary. While the advent of video-assisted thoracoscopic surgery (VATS) has enabled minimal invasive approaches for thoracic duct ligation, intraoperative identification of the thoracic duct remains technically challenging.

We present the case of a 62-year-old man diagnosed with SMARCB1-deficient mediastinal sarcoma who underwent left pneumonectomy and subsequently developed a left-sided chylothorax on postoperative day 16. Initial management with conservative strategy first, including two lymphography procedures with attempted embolization, was unsuccessful. Consequently, we proceeded with thoracic duct ligation via right-sided VATS, employing indocyanine green (ICG) fluorescence to aid in the identification of the thoracic duct. Given the prior left pneumonectomy, a single-lumen endotracheal tube with a bronchial blocker was used to selectively exclude the right lower lobe during the procedure.

This case highlights the use of ICG fluorescence in facilitating the identification and ligation of the thoracic duct in a patient with left-sided chylothorax following left pneumonectomy.

## Linked entities

- **Genes:** SMARCB1 (SWI/SNF related BAF chromatin remodeling complex subunit B1) [NCBI Gene 6598]
- **Chemicals:** indocyanine green (PubChem CID 5282412)
- **Diseases:** mediastinal sarcoma (MONDO:0002852)

## Full-text entities

- **Genes:** SMARCB1 (SWI/SNF related BAF chromatin remodeling complex subunit B1) [NCBI Gene 6598] {aka BAF47, CSS3, INI-1, INI1, MRD15, PPP1R144}
- **Diseases:** mediastinal sarcoma (MESH:D008480), Chylothorax (MESH:D002916)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12070434/full.md

## References

13 references — full list in the complete paper: https://tomesphere.com/paper/PMC12070434/full.md

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Source: https://tomesphere.com/paper/PMC12070434